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Literature summary for 2.1.1.304 extracted from

  • Tengg, M.; Stecher, H.; Offner, L.; Plasch, K.; Anderl, F.; Weber, H.; Schwab, H.; Gruber-Khadjawi, M.
    Methyltransferases green catalysts for Friedel-Crafts alkylations (2016), ChemCatChem, 8, 1354-1360 .
No PubMed abstract available
Search for more literature for 2.1.1.304

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli K12 Pseudomonas fluorescens
expression in Escherichia coli K12 Streptomyces lavendulae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + L-tyrosine Streptomyces lavendulae the enzyme is highly selective with regard to their natural substrate. The enzyme is involved in the biosynthesis of 3'-methyltyrosine, which is the precursor of the tetrahydroisoquinoline moiety in Saframycin (antibiotic) S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?
S-adenosyl-L-methionine + L-tyrosine Pseudomonas fluorescens the enzyme is involved in the biosynthesis of 3'-methyltyrosine, which is the precursor of the tetrahydroisoquinoline moiety in Safracin (antibiotic) S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas fluorescens
-
-
-
Streptomyces lavendulae B0CN31
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activity with L-DOPA is 1% of the activity with L-tyrosine Streptomyces lavendulae ?
-
-
additional information activity with L-DOPA is 2% of the activity with L-tyrosine Pseudomonas fluorescens ?
-
-
S-adenosyl-L-methionine + D-tyrosine 24% of the activity as compared to L-tyrosine Streptomyces lavendulae S-adenosyl-L-homocysteine + 3-methyl-D-tyrosine
-
 ?
S-adenosyl-L-methionine + D-tyrosine 64% of the activity as compared to L-tyrosine Pseudomonas fluorescens S-adenosyl-L-homocysteine + 3-methyl-D-tyrosine
-
 ?
S-adenosyl-L-methionine + L-tyrosine
-
 Pseudomonas fluorescens S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?
S-adenosyl-L-methionine + L-tyrosine the enzyme is highly selective with regard to their natural substrate. The enzyme is involved in the biosynthesis of 3'-methyltyrosine, which is the precursor of the tetrahydroisoquinoline moiety in Saframycin (antibiotic) Streptomyces lavendulae S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?
S-adenosyl-L-methionine + L-tyrosine the enzyme is involved in the biosynthesis of 3'-methyltyrosine, which is the precursor of the tetrahydroisoquinoline moiety in Safracin (antibiotic) Pseudomonas fluorescens S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?
S-adenosyl-L-methionine + L-tyrosine the enzyme is highly selective with regard to their natural substrate Streptomyces lavendulae S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine
-
 ?

Synonyms

Synonyms Comment Organism
SacF
-
 Pseudomonas fluorescens
SfmM2
-
 Streptomyces lavendulae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Pseudomonas fluorescens
30
-
 assay at Streptomyces lavendulae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Pseudomonas fluorescens
7
-
 assay at Streptomyces lavendulae

General Information

General Information Comment Organism
physiological function the enzyme is involved in the biosynthesis of 3'-methyltyrosine, which is the precursor of the tetrahydroisoquinoline moiety in Safracin (antibiotic) Pseudomonas fluorescens
physiological function the enzyme is involved in the biosynthesis of 3'-methyltyrosine, which is the precursor of the tetrahydroisoquinoline moiety in Saframycin (antibiotic) Streptomyces lavendulae