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Literature summary for 2.1.1.299 extracted from

  • Petkowski, J.J.; Bonsignore, L.A.; Tooley, J.G.; Wilkey, D.W.; Merchant, M.L.; Macara, I.G.; Schaner Tooley, C.E.
    NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1 (2013), Biochem. J., 456, 453-462.
    View publication on PubMed
Search for more literature for 2.1.1.299

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens
expressio in HeLa cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus when expressed in HeLa cells the enzyme is enriched in the nuclear compartment Homo sapiens 5634
-
nucleus when expressed in HeLa cells the enzyme is enriched in the nuclear compartment Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + N-terminal-Ala-Pro-Lys-[protein] Homo sapiens the enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-Ala-Pro-Lys-[protein]
-
 ?
S-adenosyl-L-methionine + N-terminal-Ala-Pro-Lys-[protein] Mus musculus the enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-Ala-Pro-Lys-[protein]
-
 ?
S-adenosyl-L-methionine + N-terminal-Pro-Pro-Lys-[protein] Homo sapiens the enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal S-adenosyl-L-homocysteine + N-terminal-N-methyl-Pro-Pro-Lys-[protein]
-
 ?
S-adenosyl-L-methionine + N-terminal-Pro-Pro-Lys-[protein] Mus musculus the enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal S-adenosyl-L-homocysteine + N-terminal-N-methyl-Pro-Pro-Lys-[protein]
-
 ?
S-adenosyl-L-methionine + N-terminal-Ser-Pro-Lys-[protein] Homo sapiens the enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal S-adenosyl-L-homocysteine + N-terminal-N-methyl-Ser-Pro-Lys-[protein]
-
 ?
S-adenosyl-L-methionine + N-terminal-Ser-Pro-Lys-[protein] Mus musculus the enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal S-adenosyl-L-homocysteine + N-terminal-N-methyl-Ser-Pro-Lys-[protein]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5VVY1
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver NRMT2 mRNA is enriched in the liver and in the skeletal muscle. Expressed at fairly low levels in all tissues examined Mus musculus
-
skeletal muscle NRMT2 mRNA is enriched in the liver and in the skeletal muscle. Expressed at fairly low levels in all tissues examined Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + N-terminal-Ala-Pro-Lys-[protein] the enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal Homo sapiens S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-Ala-Pro-Lys-[protein]
-
 ?
S-adenosyl-L-methionine + N-terminal-Ala-Pro-Lys-[protein] the enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal Mus musculus S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-Ala-Pro-Lys-[protein]
-
 ?
S-adenosyl-L-methionine + N-terminal-Pro-Pro-Lys-[protein] the enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal Homo sapiens S-adenosyl-L-homocysteine + N-terminal-N-methyl-Pro-Pro-Lys-[protein]
-
 ?
S-adenosyl-L-methionine + N-terminal-Pro-Pro-Lys-[protein] the enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal Mus musculus S-adenosyl-L-homocysteine + N-terminal-N-methyl-Pro-Pro-Lys-[protein]
-
 ?
S-adenosyl-L-methionine + N-terminal-Ser-Pro-Lys-[protein] the enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal Homo sapiens S-adenosyl-L-homocysteine + N-terminal-N-methyl-Ser-Pro-Lys-[protein]
-
 ?
S-adenosyl-L-methionine + N-terminal-Ser-Pro-Lys-[protein] the enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal Mus musculus S-adenosyl-L-homocysteine + N-terminal-N-methyl-Ser-Pro-Lys-[protein]
-
 ?

Synonyms

Synonyms Comment Organism
METTL11B
-
 Homo sapiens
METTL11B
-
 Mus musculus
N-terminal monomethylase
-
 Homo sapiens
N-terminal monomethylase
-
 Mus musculus
NRMT2
-
 Homo sapiens
NRMT2
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens