Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7,8-dichloro-1,2,3,4-tetrahydroisoquinoline | i.e. SK&F 64139 | Homo sapiens | |
7-nitro-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine | i.e. LY 134046 | Homo sapiens | |
SKF 29661 | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00054 | - |
3-trifluoromethylphenylethanolamine | pH 8.0, 30°C | Homo sapiens | |
0.0012 | - |
S-adenosyl-L-methionine | cosubstrate 3-trifluoromethylphenylethanolamine, pH 8.0, 30°C | Homo sapiens | |
0.0034 | - |
S-adenosyl-L-methionine | cosubstrate phenylethanolamine, pH 8.0, 30°C | Homo sapiens | |
0.0055 | - |
octopamine | pH 8.0, 30°C | Homo sapiens | |
0.0067 | - |
S-adenosyl-L-methionine | cosubstrate octopamine, pH 8.0, 30°C | Homo sapiens | |
0.1 | - |
phenylethanolamine | pH 8.0, 30°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P11086 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-trifluoromethylphenylethanolamine + S-adenosyl-L-methionine | - |
Homo sapiens | N-methyl-3-trifluoromethylphenylethanolamine + S-adenosyl-L-homocysteine | - |
? | |
additional information | enzyme operates by an ordered sequential mechanism in which AdoMet binds first. A protonated and an unprotonated group are required for catalysis | Homo sapiens | ? | - |
? | |
octopamine + S-adenosyl-L-methionine | - |
Homo sapiens | N-methyloctopamine + S-adenosyl-L-homocysteine | - |
? | |
phenylethanolamine + S-adenosyl-L-methionine | - |
Homo sapiens | N-methylphenylethanolamine + S-adenosyl-L-homocysteine | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
3-trifluoromethylphenylethanolamine | pH 8.0, 30°C | Homo sapiens | |
0.021 | - |
octopamine | pH 8.0, 30°C | Homo sapiens | |
0.047 | - |
phenylethanolamine | pH 8.0, 30°C | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000016 | - |
7,8-dichloro-1,2,3,4-tetrahydroisoquinoline | pH 8.0, 30°C | Homo sapiens | |
0.0000044 | - |
8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine | pH 8.0, 30°C | Homo sapiens | |
0.000078 | - |
7-nitro-1,2,3,4-tetrahydroisoquinoline | pH 8.0, 30°C | Homo sapiens | |
0.00012 | - |
SKF 29661 | pH 8.0, 30°C | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.467 | - |
phenylethanolamine | pH 8.0, 30°C | Homo sapiens | |
3.67 | - |
octopamine | pH 8.0, 30°C | Homo sapiens | |
15.5 | - |
3-trifluoromethylphenylethanolamine | pH 8.0, 30°C | Homo sapiens |