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Literature summary for 2.1.1.203 extracted from

  • Mueller, M.; Hartmann, M.; Schuster, I.; Bender, S.; Thuering, K.L.; Helm, M.; Katze, J.R.; Nellen, W.; Lyko, F.; Ehrenhofer-Murray, A.E.
    Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine (2015), Nucleic Acids Res., 43, 10952-10962 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.203

Activating Compound

Activating Compound Comment Organism Structure
queuine PMT1 is strongly stimulated by prior queuosine (Q) modification of the substrate tRNA. In vivo tRNA methylation levels are stimulated by growth of cells in queuine-containing medium, in vitro Pmt1 activity is enhanced on Q-containing RNA; and queuine-stimulated in vivo methylation is abrogated by the absence of the eukaryotic tRNA-guanine transglycosylase Schizosaccharomyces pombe
queuine the addition of queuine to the growth medium increases C38 methylation from 10 to 100%, while other cytosines remain unaffected Dictyostelium discoideum

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum Q54JH6 cf. EC 2.1.1.37
-
Schizosaccharomyces pombe P40999 cf. EC 2.1.1.204
-
Schizosaccharomyces pombe 972 P40999 cf. EC 2.1.1.204
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + cytosine34 in tRNAPro
-
 Schizosaccharomyces pombe S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNAPro
-
 ?
S-adenosyl-L-methionine + cytosine34 in tRNAPro
-
 Dictyostelium discoideum S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNAPro
-
 ?
S-adenosyl-L-methionine + cytosine34 in tRNAPro
-
 Schizosaccharomyces pombe 972 S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNAPro
-
 ?

Synonyms

Synonyms Comment Organism
DnmA
-
 Dictyostelium discoideum
PMT1
-
 Schizosaccharomyces pombe
PMT1
-
 Dictyostelium discoideum