Protein Variants | Comment | Organism |
---|---|---|
A135T | inactive | Streptococcus pneumoniae |
C23R | inactive | Streptococcus pneumoniae |
C36R | inactive | Streptococcus pneumoniae |
L113P | inactive | Streptococcus pneumoniae |
L164P | inactive | Streptococcus pneumoniae |
L165P | inactive | Streptococcus pneumoniae |
L247P | inactive | Streptococcus pneumoniae |
R200C | inactive | Streptococcus pneumoniae |
Y212C | inactive | Streptococcus pneumoniae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
31500 | - |
x * 31500, calculated from amino acid sequence | Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanine748 in 23S rRNA | Streptococcus pneumoniae | - |
S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA | - |
? | |
S-adenosyl-L-methionine + guanine748 in 23S rRNA | Streptococcus pneumoniae S1 | - |
S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | - |
- |
- |
Streptococcus pneumoniae S1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanine748 in 23S rRNA | - |
Streptococcus pneumoniae | S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA | - |
? | |
S-adenosyl-L-methionine + guanine748 in 23S rRNA | - |
Streptococcus pneumoniae S1 | S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 31500, calculated from amino acid sequence | Streptococcus pneumoniae |
Synonyms | Comment | Organism |
---|---|---|
RlmAII | - |
Streptococcus pneumoniae |
TlrB | - |
Streptococcus pneumoniae |
General Information | Comment | Organism |
---|---|---|
malfunction | the inactivation of the enzyme confers telithromycin resistance | Streptococcus pneumoniae |
physiological function | methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible | Streptococcus pneumoniae |