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Literature summary for 2.1.1.170 extracted from

  • Benitez-Paez, A.; Cardenas-Brito, S.; Corredor, M.; Villarroya, M.; Armengod, M.E.
    Impairing methylations at ribosome RNA, a point mutation-dependent strategy for aminoglycoside resistance: The rsmG case (2014), Biomedica, 34, 41-49.
    View publication on PubMed
Search for more literature for 2.1.1.170

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Escherichia coli

Protein Variants

Protein Variants Comment Organism
G75A the mutation directly affects the S-adenosyl-L-methionine binding site, presents an almost 4fold loss of affinity and maintains the enzyme active Escherichia coli
N39A inactive Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + guanine527 in 16S rRNA Escherichia coli
-
 S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A6U5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + guanine527 in 16S rRNA
-
 Escherichia coli S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA
-
 ?

Synonyms

Synonyms Comment Organism
rsmG
-
 Escherichia coli

General Information

General Information Comment Organism
malfunction enzyme loss confers low-level streptomycin resistance and may affect ribosomal functioning Escherichia coli