Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.142 extracted from

  • Kaneshiro, E.; Johnston, L.; Nkinin, S.; Romero, B.; Giner, J.
    Sterols of Saccharomyces cerevisiae erg6 knockout mutant expressing the Pneumocystis carinii S-adenosylmethionine sterol C-24 methyltransferase (SAM SMT) (2015), J. Eukaryot. Microbiol., 62, 298-306 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.142

Organism

Organism UniProt Comment Textmining
Pneumocystis carinii Q96WX4 enzyme catalyzes both the reactions of EC 2.1.1.41 and EC 2.1.1.142
-
Pneumocystis carinii B80 Q96WX4 enzyme catalyzes both the reactions of EC 2.1.1.41 and EC 2.1.1.142
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + lanosterol
-
 Pneumocystis carinii S-adenosyl-L-homocysteine + 24(28)-methylene-24,25-dihydro-lanosterol
-
 ?
S-adenosyl-L-methionine + lanosterol
-
 Pneumocystis carinii B80 S-adenosyl-L-homocysteine + 24(28)-methylene-24,25-dihydro-lanosterol
-
 ?

Subunits

Subunits Comment Organism
? x * 43000, SDS-PAGE Pneumocystis carinii

Synonyms

Synonyms Comment Organism
Erg6
-
 Pneumocystis carinii
SAM:SMT
-
 Pneumocystis carinii

General Information

General Information Comment Organism
physiological function enzyme transfers either one or two methyl groups to the C-24 position of the sterol side chain producing both C28 and C29 24-alkylsterols in approximately the same proportions. Expression of SAM:SMT in a Saccharomyces cerevisiae Erg6 mutant restores its ability to produce ergosterol as the major sterol, and also results in low levels of C29 sterols such as pneumocysterol Pneumocystis carinii