Literature summary for 2.1.1.142 extracted from

Rahier, A.; Genot, J.C.; Schuber, F.; Benveniste, P.; Narula, A.S.
Inhibition of S-adenosyl-L-methionine sterol-C-24-methyltransferase by analogues of a carbocationic ion high-energy intermediate. Structure activity relationships for C-25 heteroatoms (N, As, S) substituted triterpenoid derivatives (1984), J. Biol. Chem., 259, 15215-15223.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(24R)-24-methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol	-	Zea mays
(24R)-24-methyl-25-azacycloartenol	-	Zea mays
(24R,S)-24-Ethyl-25-azacycloartenol	-	Zea mays
(24R,S)-24-Methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol	-	Zea mays
(24R,S)-24-Methyl-25,26,27-trisnor-24-dimethylsulfonium cycloartenol iodide	-	Zea mays
(24R,S)-24-Methyl-25,26,27-trisnor-24-trimethylarsonium cycloartenol iodide	-	Zea mays
(24R,S)-24-Methyl-25-azacycloartenol	-	Zea mays
(24S)-24-methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol	-	Zea mays
(24S)-24-methyl-25-azacycloartenol	-	Zea mays
23-Azacholesterol	-	Zea mays
24-Azacholesterol	-	Zea mays
24-Azacycloartanyl acetate	-	Zea mays
24-Methyl-25,26,27-trisnor-24-trimethylammonium cycloartenol iodide	24R and 24S isomer	Zea mays
24-Methyl-25-azacycloartenol	24R and 24S isomer	Zea mays
24-Oxo-25-azacycloartenol	-	Zea mays
25,26,27-Trisnor-24-trimethylammonium cycloartenol iodide	-	Zea mays
25-Azacholesterol	-	Zea mays
25-Azacycloartenol	-	Zea mays

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Zea mays	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cycloartenol + S-adenosyl-L-methionine	Zea mays	cycloartenol is 4,4,14alpha-trimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol	24-methylenecycloartanol + S-adenosyl-L-homocysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Zea mays	-	corn	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
seedling	-	Zea mays	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cycloartenol + S-adenosyl-L-methionine	cycloartenol is 4,4,14alpha-trimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol	Zea mays	24-methylenecycloartanol + S-adenosyl-L-homocysteine	-	?
zymosterol + S-adenosyl-L-methionine	-	Zea mays	fecosterol + S-adenosyl-L-homocysteine	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000015	-	(24R)-24-methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol	-	Zea mays
0.00002	-	(24R,S)-24-Methyl-25-azacycloartenol	-	Zea mays
0.00002	-	(24R)-24-methyl-25-azacycloartenol	-	Zea mays
0.000025	-	(24R,S)-24-Methyl-25,26,27-trisnor-24-trimethylarsonium cycloartenol iodide	-	Zea mays
0.00003	-	25-Azacycloartenol	-	Zea mays
0.00003	-	24-Azacycloartanyl acetate	-	Zea mays
0.00003	-	(24S)-24-methyl-25-azacycloartenol	-	Zea mays
0.000035	-	24-Methyl-25,26,27-trisnor-24-trimethylammonium cycloartenol iodide	-	Zea mays
0.000035	-	25,26,27-Trisnor-24-trimethylammonium cycloartenol iodide	-	Zea mays
0.000045	-	25-Azacholesterol	-	Zea mays
0.000045	-	(24S)-24-methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol	-	Zea mays
0.00005	-	(24R,S)-24-Methyl-25,26,27-trisnor-24-dimethylsulfonium cycloartenol iodide	-	Zea mays
0.000085	-	(24R,S)-24-Ethyl-25-azacycloartenol	-	Zea mays
0.00009	-	23-Azacholesterol	-	Zea mays
0.00017	-	24-Oxo-25-azacycloartenol	-	Zea mays
0.00018	-	24-Azacholesterol	-	Zea mays

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Release 2023.1 (January 2023)