Literature summary for 2.1.1.1 extracted from

van Haren, M.J.; Taig, R.; Kuppens, J.; Sastre Torano, J.; Moret, E.E.; Parsons, R.B.; Sartini, D.; Emanuelli, M.; Martin, N.I.
Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state (2017), Org. Biomol. Chem., 15, 6656-6667 .

Search for more literature for 2.1.1.1

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
3-(6-amino-6-oxohexyl)benzamide	inhibitor mimics the transition state of the methylation reaction	Homo sapiens
4-methyl-N'-methylnicotinamide	-	Homo sapiens
5'-[[(3S)-3-amino-3-carboxypropyl][(3-carbamoylphenyl)methyl]amino]-5'-deoxyadenosine	inhibitor mimics the transition state of the methylation reaction	Homo sapiens
7-(3-carbamoylphenyl)hept-6-ynoic acid	inhibitor mimics the transition state of the methylation reaction	Homo sapiens
N'-methyl-nicotinamide	-	Homo sapiens
norharmane	-	Homo sapiens
S-adenosyl-L-homocysteine	-	Homo sapiens
sinefungin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P40261	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.017	-	pH 8.6, 37°C	Homo sapiens	sinefungin
0.025	-	pH 8.6, 37°C	Homo sapiens	N'-methyl-nicotinamide
0.029	-	pH 8.6, 37°C	Homo sapiens	5'-[[(3S)-3-amino-3-carboxypropyl][(3-carbamoylphenyl)methyl]amino]-5'-deoxyadenosine
0.031	-	pH 8.6, 37°C	Homo sapiens	3-(6-amino-6-oxohexyl)benzamide
0.058	-	pH 8.6, 37°C	Homo sapiens	7-(3-carbamoylphenyl)hept-6-ynoic acid
0.075	-	pH 8.6, 37°C	Homo sapiens	S-adenosyl-L-homocysteine
0.099	-	pH 8.6, 37°C	Homo sapiens	4-methyl-N'-methylnicotinamide
0.115	-	pH 8.6, 37°C	Homo sapiens	norharmane

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Release 2023.1 (January 2023)