Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Nickel | exposure of BEAS-2B cells to induces NNMT repression at both the protein and mRNA levels | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P40261 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BEAS-2B cell | - |
Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | exposure of BEAS-2B cells to induces NNMT repression at both the protein and mRNA levels | down |
Homo sapiens | exposure to nickel induces NNMT repression at both the protein and mRNA levels | down |
General Information | Comment | Organism |
---|---|---|
physiological function | exposure of BEAS-2B cells to nickel increases histone H3K9 dimethylation (H3K9me2), suppresses the expressions of H3K9me2-associated genes MAP2K3 and DKK1, and induces NNMT repression at both the protein and mRNA levels. Over-expression of NNMT inhibits nickel-induced H3K9me2 and alters the cellular SAM/SAH ratio | Homo sapiens |
physiological function | exposure of BEAS-2B cells to nickel increases histone H3K9 dimethylation, suppresses the expressions of H3K9me2-associated genes MAP2K3 and DKK1, and induces NNMT repression at both the protein and mRNA levels. Overexpression of NNMT inhibits nickel-induced H3K9me2 and alters the cellular SAM/SAH ratio | Homo sapiens |