Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-methylnicotinamide | product inhibition | Homo sapiens | |
S-adenosyl-L-homocysteine | product inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | - |
nicotinamide | pH 8.6, 37°C | Homo sapiens | |
0.01 | - |
S-adenosyl-L-methionine | pH 8.6, 37°C | Homo sapiens | |
0.01 | - |
Quinoline | pH 8.6, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P40261 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant protein | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | NNMT uses a rapid equilibrium ordered mechanism, where NNMT first binds S-adenosyl-L-methionine, which is followed by nicotinamide. Methyl transfer occurs, and methylated nicotinamide and S-adenosylhomocysteine are released consecutively | Homo sapiens | ? | - |
- |
|
S-adenosyl-L-methionine + nicotinamide | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? | |
S-adenosyl-L-methionine + quinoline | - |
Homo sapiens | S-adenosyl-L-homocysteine + N-methylquinoline | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
S-adenosyl-L-methionine | pH 8.6, 37°C | Homo sapiens | |
0.011 | - |
Quinoline | pH 8.6, 37°C | Homo sapiens | |
0.014 | - |
nicotinamide | pH 8.6, 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0012 | - |
substrate S-adenosyl-L-methionine, pH 8.6, 37°C | Homo sapiens | S-adenosyl-L-homocysteine | |
0.002 | - |
substrate quinoline, pH 8.6, 37°C | Homo sapiens | S-adenosyl-L-homocysteine | |
0.023 | - |
substrate quinoline, pH 8.6, 37°C | Homo sapiens | 1-methylnicotinamide |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.75 | - |
S-adenosyl-L-methionine | pH 8.6, 37°C | Homo sapiens | |
1.1 | - |
Quinoline | pH 8.6, 37°C | Homo sapiens | |
4.7 | - |
nicotinamide | pH 8.6, 37°C | Homo sapiens |