Literature summary for 1.8.4.11 extracted from

Singh, M.P.; Kwak, G.H.; Kim, K.Y.; Kim, H.Y.
Methionine sulfoxide reductase A protects hepatocytes against acetaminophen-induced toxicity via regulation of thioredoxin reductase 1 expression (2017), Biochem. Biophys. Res. Commun., 487, 695-701 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9D6Y7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
methionine sulfoxide reductase A	-	Mus musculus
MsrA	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	MsrA deficiency increases both basal and acetaminophen-induced thioredoxin reductase 1 expression levels, likely through increased Nrf2 activation. Conversely, MsrA overexpression diminishes the augmented thioredoxin reductase 1 levels in acetaminophen-treated MsrA(-/-) hepatocytes, reducing susceptibility against acetaminophen-induced cytotoxicity	Mus musculus
physiological function	the enzyme protects hepatocytes against acetaminophen-induced toxicity via regulation of thioredoxin reductase 1 expression	Mus musculus

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Release 2023.1 (January 2023)