Cloned (Comment) | Organism |
---|---|
expression of MsrA in Escherichia coli strain BL21(DE3) | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
calmodulin L-methionine-(S)-sulfoxide + thioredoxin | Rattus norvegicus | MsrA is specific for the S-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues, which restores the calmodulin binding to adenylate cyclase of the pathogen Bordetella pertussis, which is an essential step for the bacterium to enter host cells, overview | calmodulin L-methionine + thioredoxin disulfide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant MsrA from Escherichia coli strain BL21(DE3) | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
calmodulin L-methionine-(S)-sulfoxide + thioredoxin | MsrA is specific for the S-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues, which restores the calmodulin binding to adenylate cyclase of the pathogen Bordetella pertussis, which is an essential step for the bacterium to enter host cells, overview | Rattus norvegicus | calmodulin L-methionine + thioredoxin disulfide | - |
? | |
calmodulin L-methionine-(S)-sulfoxide + thioredoxin | MsrA is specific for the S-form, recombinant human calmodulin, recombinant rat enzyme, artificial system, determination of oxidized methionine residues being reduced by the enzyme, overview | Rattus norvegicus | calmodulin L-methionine + thioredoxin disulfide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MsrA | - |
Rattus norvegicus |
peptide methionine sulfoxide reductase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Rattus norvegicus |