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Literature summary for 1.8.3.7 extracted from
- Formylglycine-generating enzymes for site-specific bioconjugation (2019), Biol. Chem., 400, 289-297 .
Application
| Application | Comment | Organism |
|---|---|---|
| biotechnology | site-specific bioconjugation. Formylglycine-generating enzymes allow to posttranslationally introduce the amino acid Calpha-formylglycine (FGly) into recombinant proteins, starting from cysteine or serine residues within distinct consensus motifs | Mycobacterium tuberculosis |
| biotechnology | site-specific bioconjugation. Formylglycine-generating enzymes allow to posttranslationally introduce the amino acid Calpha-formylglycine (FGly) into recombinant proteins, starting from cysteine or serine residues within distinct consensus motifs | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q8NBK3 | - |
- |
| Mycobacterium tuberculosis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a [sulfatase]-L-cysteine + O2 + 2 a thiol | preference of the enzyme for CXPXR-type motifs | Mycobacterium tuberculosis | a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O | - |
? |  |
| a [sulfatase]-L-cysteine + O2 + 2 a thiol | preference of the enzyme for CXPXR-type motifs | Homo sapiens | a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FGE | - |
Mycobacterium tuberculosis |
| FGE | - |
Homo sapiens |
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