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Literature summary for 1.8.3.7 extracted from

  • Takakusaki, Y.; Hisayasu, S.; Hirai, Y.; Shimada, T.
    Coexpression of formylglycine-generating enzyme is essential for synthesis and secretion of functional arylsulfatase A in a mouse model of metachromatic leukodystrophy (2005), Hum. Gene Ther., 16, 929-936 .
    View publication on PubMed
Search for more literature for 1.8.3.7

Application

Application Comment Organism
medicine coexpression of formylglycine-generating enzyme is essential for gene therapy of metachromatic leukodystrophy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a [sulfatase]-L-cysteine + O2 + a thiol Homo sapiens
-
 a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a [sulfatase]-L-cysteine + O2 + a thiol
-
 Homo sapiens a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
FGE
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the expression of endogenous enzyme is particularly low in human brain down