Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cysteine | part of the active site | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arsenite | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0025 | - |
thioredoxin | substrate: thioredoxin from calf and rat | Rattus norvegicus | |
0.0025 | - |
reductase | thioredoxin from rat, bovine substrate | Rattus norvegicus | |
0.006 | - |
NADPH | - |
Rattus norvegicus | |
0.045 | - |
thioredoxin | substrate: thioredoxin from E. coli | Rattus norvegicus | |
0.66 | - |
DTNB | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58000 | - |
2 * 58000, SDS-PAGE | Rattus norvegicus |
116000 | - |
gel filtration | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
35 | - |
purified enzyme, coupled assay with DTNB | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | i.e. DTNB | Rattus norvegicus | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | coupled assay | Rattus norvegicus | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
alloxan + NADPH | - |
Rattus norvegicus | ? | - |
? | |
L-cysteine + NADPH | - |
Rattus norvegicus | L-cystine + NADP+ | - |
? | |
menadione + NADPH | - |
Rattus norvegicus | ? | - |
? | |
oxidized lipoamide + NADPH | - |
Rattus norvegicus | lipoamide disulfide + NADP+ | - |
? | |
thioredoxin + NADP+ | - |
Rattus norvegicus | thioredoxin disulfide + NADPH | - |
ir | |
thioredoxin + NADP+ | - |
Rattus norvegicus | thioredoxin disulfide + NADPH + H+ | - |
ir |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 58000, SDS-PAGE | Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
50 | - |
thioredoxin | - |
Rattus norvegicus | |
66.7 | - |
DTNB | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Rattus norvegicus | |
NADPH | - |
Rattus norvegicus |