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Literature summary for 1.8.1.8 extracted from

  • Swerdlow, R.D.; Green, C.L.; Setlow, B.; Setlow, P.
    Identification of an NADH-linked disulfide reductase from Bacillus megaterium specific for disulfides containing pantethine 4',4''-diphosphate moieties (1979), J. Biol. Chem., 254, 6835-6837.
    View publication on PubMed
Search for more literature for 1.8.1.8

Organism

Organism UniProt Comment Textmining
Priestia megaterium
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Purification (Commentary)

Purification (Comment) Organism
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 Priestia megaterium

Source Tissue

Source Tissue Comment Organism Textmining
spore highest level in cells late in sporulation and in dormant spores Priestia megaterium
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the partially purified enzyme has no activity with cystine, GSSG or lipoic acid, and has high activity only with disulfides containing pantethine 4’,4”-diphosphate moieties either alone or as part of CoA. The enzyme utilizes only NADH as a reductant and is inactive with NADPH Priestia megaterium ?
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 ?
NADH + CoA-SS-CoA + H+
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 Priestia megaterium NAD+ + CoA
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 ?
NADH + CoA-SS-pantetheine-4'-phosphate
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 Priestia megaterium NAD+ + CoA + 4'-phosphopantetheine
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 ?
NADH + pantethine 4',4''-diphosphate + H+
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 Priestia megaterium NAD+ + 4'-phosphopantetheine
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 ?

Synonyms

Synonyms Comment Organism
NADH-linked disulfide reductase
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 Priestia megaterium