Literature summary for 1.6.5.2 extracted from

Bian, J.; Li, X.; Xu, L.; Wang, N.; Qian, X.; You, Q.; Zhang, X.
Affinity-based small fluorescent probe for NAD(P)H quinone oxidoreductase 1 (NQO1). Design, synthesis and pharmacological evaluation (2017), Eur. J. Med. Chem., 127, 828-839 .

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Application

Application	Comment	Organism
analysis	development of a functional affinity-based small-molecule probe composed of a potent small-molecule NQO1 inhibitor 4-hydroxy-3-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2H-1-benzopyran-2-one as the recognition group, a linker and the fluorophores group FITC. The probe exhibits good inhibitory activity of NQO1 and can be used to label the protein in A549 cells at the micromolar level	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
4-hydroxy-3-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2H-1-benzopyran-2-one	10 microM, 89.2% inhibition. At 0.0084 microM, 50% toxicity in A549 cells in the presence of 20 mM beta-lapachone. Inhibitor is used to built a functional affinity-based small-molecule fluoresent probe composed of the NQO1 inhibitor as the recognition group, a linker and the fluorophores group FITC	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15559	-	-

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Release 2023.1 (January 2023)