Literature summary for 1.5.3.16 extracted from

Leonetti, A.; Baroli, G.; Fratini, E.; Pietropaoli, S.; Marcoli, M.; Mariottini, P.; Cervelli, M.
Epileptic seizures and oxidative stress in a mouse model over-expressing spermine oxidase (2020), Amino Acids, 52, 129-139 .

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Application

Application	Comment	Organism
medicine	spermine oxidase, as a hydrogen peroxide producer, may be involved in the oxidative stress during epilepsy. In a mouse model overexpressing SMOX specifically in the brain cortex, transgenic mice compared to controls showed a higher susceptibility towards pentylentetrazole and display an altered polyamine content with rise of 8-oxo-7,8-dihydro-2'-deoxyguanosine level, and an augmentation of system xc as a defence mechanism	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q99K82	-	-

General Information

General Information	Comment	Organism
physiological function	spermine oxidase, as a hydrogen peroxide producer, may be involved in the oxidative stress during epilepsy. In a mouse model overexpressing SMOX specifically in the brain cortex, transgenic mice compared to controls showed a higher susceptibility towards pentylentetrazole and display an altered polyamine content with rise of 8-oxo-7,8-dihydro-2'-deoxyguanosine level, and an augmentation of system xc- as a defence mechanism	Mus musculus

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Release 2023.1 (January 2023)