Application | Comment | Organism |
---|---|---|
pharmacology | N,N'-butanedienyl butanediamine, i.e. MDL 72527 or CPC-200, a small molecule specific inhibitor of polyamine oxidase, effectively blocks androgen-induced reactive oxygen species production in human prostate cancer cells, as well as significantly delays prostate cancer progression and death in animals developing spontaneous prostate cancer | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N,N'-butanedienyl butanediamine | i.e. MDL 72527 or CPC-200, a small molecule specific inhibitor of polyamine oxidase, effectively blocks androgen-induced reactive oxygen species production in human prostate cancer cells, as well as significantly delays prostate cancer progression and death in animals developing spontaneous prostate cancer | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
colonic cancer cell | - |
Homo sapiens | - |
LNCaP cell | androgen-treated and untreated prostate adenocarcinoma cells | Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
APAO | - |
Homo sapiens |
N1-acetyl polyamine oxidase | - |
Homo sapiens |
PAO | - |
Homo sapiens |
PAOh1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | polyamine oxidation is a major pathway for reactive oxygen species production in prostate, inhibiting this pathway successfully delays prostate cancer progression | Homo sapiens |