Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | FDH-expressing cells show accumulation of cells in G0-G1 phase and a sharp decrease of cells in S phase. Accumulation of the tumor suppressor protein p53 and its downstream target p21. FDH antiproliferative effects on A549 cells include both G1 cell cycle arrest and caspase-dependent apoptosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | inducible expression of 10-formyltetrahydrofolate dehydrogenase | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + NADP+ + H2O | - |
Homo sapiens | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
additional information | FDH-expressing cells show accumulation of cells in G0-G1 phase and a sharp decrease of cells in S phase. Accumulation of the tumor suppressor protein p53 and its downstream target p21. FDH antiproliferative effects on A549 cells include both G1 cell cycle arrest and caspase-dependent apoptosis | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
10-formyltetrahydrofolate dehydrogenase | - |
Homo sapiens |
FDH | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens |