Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | - |
Crithidia fasciculata | |
additional information | overview antifolate inhibitors, especially methotrexate, and sensitivity or resistance in plants | Datura inoxia | |
additional information | overview antifolate inhibitors, especially methotrexate, and sensitivity or resistance in plants | Daucus carota | |
additional information | overview antifolate inhibitors, especially methotrexate, and sensitivity or resistance in plants | Glycine max | |
additional information | overview antifolate inhibitors, especially methotrexate, and sensitivity or resistance in plants | Nicotiana plumbaginifolia | |
additional information | overview antifolate inhibitors, especially methotrexate, and sensitivity or resistance in plants | Nicotiana tabacum | |
additional information | overview antifolate inhibitors, especially methotrexate, and sensitivity or resistance in plants | Petunia x hybrida | |
additional information | - |
Tetradesmus obliquus | |
additional information | overview antifolate inhibitors, especially methotrexate, and sensitivity or resistance in plants | Zea mays |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Leishmania tropica | |
additional information | - |
additional information | overview | Tetradesmus obliquus | |
additional information | - |
additional information | overview | Pisum sativum | |
additional information | - |
additional information | overview | Glycine max | |
additional information | - |
additional information | overview | Crithidia fasciculata | |
additional information | - |
additional information | overview | Daucus carota | |
additional information | - |
additional information | overview | Oryza sativa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
overview | Tetradesmus obliquus |
additional information | - |
overview | Glycine max |
additional information | - |
overview | Crithidia fasciculata |
additional information | - |
overview | Daucus carota |
additional information | - |
overview | Leishmania tropica |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crithidia fasciculata | - |
- |
- |
Datura inoxia | - |
- |
- |
Daucus carota | - |
- |
- |
Euglena gracilis | - |
- |
- |
Glycine max | - |
- |
- |
Leishmania tropica | - |
- |
- |
Nicotiana plumbaginifolia | - |
- |
- |
Nicotiana tabacum | - |
- |
- |
Oryza sativa | - |
- |
- |
Petunia x hybrida | - |
- |
- |
Pisum sativum | - |
- |
- |
Tetradesmus obliquus | - |
- |
- |
Zea mays | - |
- |
- |
Purification (Comment) | Organism |
---|---|
overview | Tetradesmus obliquus |
overview | Glycine max |
overview | Daucus carota |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ | bifunctional proteins with DHFR and thymidylate synthase activity | Tetradesmus obliquus | |
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ | bifunctional proteins with DHFR and thymidylate synthase activity | Crithidia fasciculata | |
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ | bifunctional proteins with DHFR and thymidylate synthase activity | Daucus carota |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
seedling | - |
Pisum sativum | - |
seedling | - |
Glycine max | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Leishmania tropica |
additional information | - |
overview | Glycine max |
additional information | - |
overview | Daucus carota |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + NADPH | - |
Tetradesmus obliquus | 5,6,7,8-tetrahydrofolate + NADP+ | - |
r | |
7,8-dihydrofolate + NADPH | - |
Euglena gracilis | 5,6,7,8-tetrahydrofolate + NADP+ | - |
r | |
7,8-dihydrofolate + NADPH | - |
Pisum sativum | 5,6,7,8-tetrahydrofolate + NADP+ | - |
r | |
7,8-dihydrofolate + NADPH | - |
Zea mays | 5,6,7,8-tetrahydrofolate + NADP+ | - |
r | |
7,8-dihydrofolate + NADPH | - |
Nicotiana tabacum | 5,6,7,8-tetrahydrofolate + NADP+ | - |
r | |
7,8-dihydrofolate + NADPH | - |
Glycine max | 5,6,7,8-tetrahydrofolate + NADP+ | - |
r | |
7,8-dihydrofolate + NADPH | - |
Crithidia fasciculata | 5,6,7,8-tetrahydrofolate + NADP+ | - |
r | |
7,8-dihydrofolate + NADPH | - |
Datura inoxia | 5,6,7,8-tetrahydrofolate + NADP+ | - |
r | |
7,8-dihydrofolate + NADPH | - |
Daucus carota | 5,6,7,8-tetrahydrofolate + NADP+ | - |
r | |
7,8-dihydrofolate + NADPH | - |
Oryza sativa | 5,6,7,8-tetrahydrofolate + NADP+ | - |
r | |
7,8-dihydrofolate + NADPH | - |
Petunia x hybrida | 5,6,7,8-tetrahydrofolate + NADP+ | - |
r | |
7,8-dihydrofolate + NADPH | - |
Nicotiana plumbaginifolia | 5,6,7,8-tetrahydrofolate + NADP+ | - |
r | |
7,8-dihydrofolate + NADPH | - |
Leishmania tropica | 5,6,7,8-tetrahydrofolate + NADP+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Tetradesmus obliquus |
dimer | - |
Crithidia fasciculata |
dimer | - |
Leishmania tropica |
More | overview | Tetradesmus obliquus |
More | overview | Glycine max |
More | overview | Daucus carota |
More | bifunctional, homodimers with DHFR and TS domains for each monomer | Crithidia fasciculata |
More | bifunctional, homodimers with DHFR and TS domains for each monomer | Leishmania tropica |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
overview | Tetradesmus obliquus |
additional information | - |
overview | Pisum sativum |
additional information | - |
overview | Glycine max |
additional information | - |
overview | Daucus carota |
additional information | - |
overview | Oryza sativa |