BRENDA - Enzyme Database show
show all sequences of 1.4.4.2

Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia

Kikuchi, G.; Motokawa, Y.; Yoshida, T.; Hiraga, K.; Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 84, 246-263 (2008)

Data extracted from this reference:

Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
200000
-
value about
Escherichia coli
200000
-
value about
Gallus gallus
200000
-
value about
Gottschalkia acidurici
200000
-
value about
Homo sapiens
200000
-
value about
Peptoclostridium acidaminophilum
200000
-
value about
Pisum sativum
200000
-
value about
Thermus thermophilus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Escherichia coli
-
-
-
Gallus gallus
-
-
-
Gottschalkia acidurici
-
-
-
Homo sapiens
-
-
-
Peptoclostridium acidaminophilum
-
-
-
Pisum sativum
-
-
-
Thermus thermophilus
-
-
-
Subunits
Subunits
Commentary
Organism
dimer
dimer of heterodimer
Gottschalkia acidurici
dimer
dimer of heterodimer
Peptoclostridium acidaminophilum
dimer
dimer of heterodimer
Thermus thermophilus
homodimer
-
Escherichia coli
homodimer
-
Gallus gallus
homodimer
-
Homo sapiens
homodimer
-
Pisum sativum
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
200000
-
value about
Escherichia coli
200000
-
value about
Gallus gallus
200000
-
value about
Gottschalkia acidurici
200000
-
value about
Homo sapiens
200000
-
value about
Peptoclostridium acidaminophilum
200000
-
value about
Pisum sativum
200000
-
value about
Thermus thermophilus
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
dimer of heterodimer
Gottschalkia acidurici
dimer
dimer of heterodimer
Peptoclostridium acidaminophilum
dimer
dimer of heterodimer
Thermus thermophilus
homodimer
-
Escherichia coli
homodimer
-
Gallus gallus
homodimer
-
Homo sapiens
homodimer
-
Pisum sativum
General Information
General Information
Commentary
Organism
physiological function
part of glycine cleavage system
Escherichia coli
physiological function
part of glycine cleavage system
Gallus gallus
physiological function
part of glycine cleavage system
Gottschalkia acidurici
physiological function
part of glycine cleavage system
Homo sapiens
physiological function
part of glycine cleavage system
Peptoclostridium acidaminophilum
physiological function
part of glycine cleavage system
Pisum sativum
physiological function
part of glycine cleavage system
Thermus thermophilus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
part of glycine cleavage system
Escherichia coli
physiological function
part of glycine cleavage system
Gallus gallus
physiological function
part of glycine cleavage system
Gottschalkia acidurici
physiological function
part of glycine cleavage system
Homo sapiens
physiological function
part of glycine cleavage system
Peptoclostridium acidaminophilum
physiological function
part of glycine cleavage system
Pisum sativum
physiological function
part of glycine cleavage system
Thermus thermophilus
Other publictions for EC 1.4.4.2
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741906
Go
Glycine decarboxylase is an u ...
Homo sapiens
Biochemistry
53
947-956
2014
3
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1
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7
1
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1
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5
5
743023
Azize
Mutation analysis of glycine ...
Homo sapiens
J. Hum. Genet.
59
593-597
2014
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1
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743266
Varadarajan
Plasmodium berghei glycine cl ...
no activity in Plasmodium berghei
Mol. Biochem. Parasitol.
197
50-55
2014
-
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724693
Dominy
Glycine decarboxylase cleaves ...
Mus musculus
Cancer Cell
21
143-145
2012
-
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1
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1
1
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725016
Timm
Glycine decarboxylase controls ...
Arabidopsis thaliana
FEBS Lett.
586
3692-3697
2012
-
-
-
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1
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1
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3
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1
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1
1
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-
724197
Zay
Glycine cleavage enzyme comple ...
Homo sapiens
Biochem. Cell Biol.
89
299-307
2011
-
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1
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1
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5
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2
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1
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725115
Zhang
-
Transcriptionally and phylogen ...
Brassica napus
Hortic. Environ. Biotechnol.
52
427-434
2011
-
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1
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710748
Hasse
Crystallization and preliminar ...
Synechocystis sp.
Acta Crystallogr. Sect. F
66
187-191
2010
-
-
1
1
-
-
-
-
-
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1
1
-
4
-
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1
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1
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1
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1
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1
1
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1
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2
1
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-
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2
2
-
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-
713311
Palmieri
Regulation of plant glycine de ...
Arabidopsis thaliana
Plant Physiol.
152
1514-1528
2010
-
-
-
-
-
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5
-
1
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3
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1
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1
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1
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1
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1
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3
3
-
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-
719865
Okamura-Ikeda
Crystal structure of aminometh ...
Escherichia coli
J. Biol. Chem.
285
18684-18692
2010
-
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1
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4
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1
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697916
Hasse
Alternative splicing produces ...
Flaveria trinervia
FEBS J.
276
6985-6991
2009
-
-
1
-
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1
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6
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1
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3
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1
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3
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-
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698096
Kawaguchi
Genomic organization of region ...
Gallus gallus
Gene
432
7-18
2009
-
-
-
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-
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-
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1
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2
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688637
Parys
Mitochondria from leaf mesophy ...
Zea mays
J. Plant Physiol.
165
1061-1069
2008
-
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1
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6
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1
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1
1
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-
689605
Engelmann
The gene for the P-subunit of ...
Flaveria trinervia
Plant Physiol.
146
1773-1785
2008
-
-
1
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5
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3
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3
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1
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-
706478
Kikuchi
Glycine cleavage system: react ...
Escherichia coli, Gallus gallus, Gottschalkia acidurici, Homo sapiens, Peptoclostridium acidaminophilum, Pisum sativum, Thermus thermophilus
Proc. Jpn. Acad. Ser. B Phys. Biol. Sci.
84
246-263
2008
-
-
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7
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11
-
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7
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7
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7
-
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7
7
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-
686720
Hasse
Properties of recombinant glyc ...
Synechocystis sp.
FEBS Lett.
581
1297-1301
2007
-
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1
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11
-
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2
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1
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4
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1
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1
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1
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11
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1
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4
-
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1
-
1
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688072
Rajinikanth
The glycine decarboxylase comp ...
Populus tremuloides
J. Exp. Bot.
58
1761-1770
2007
-
-
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1
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5
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6
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6
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689575
Engel
Deletion of glycine decarboxyl ...
Arabidopsis thaliana
Plant Physiol.
144
1328-1335
2007
-
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1
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1
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4
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673411
Mukherjee
Proteins of the glycine decarb ...
Trichomonas vaginalis
Eukaryot. Cell
5
2062-2071
2006
-
-
1
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5
2
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6
1
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4
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1
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3
2
1
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4
1
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1
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5
2
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6
1
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1
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3
2
1
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4
1
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676615
Eisenhut
The plant-like C2 glycolate cy ...
Synechocystis sp., Synechocystis sp. PCC 6803
Plant Physiol.
142
333-342
2006
-
1
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2
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1
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6
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1
1
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1
1
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655343
Nakai
Structure of P-protein of the ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
EMBO J.
24
1523-1536
2005
-
-
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1
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1
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91
-
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1
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656820
Sellner
Detection of mutations in the ...
Homo sapiens
Mol. Genet. Metab.
84
167-171
2005
-
-
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1
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1
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660325
Bykova
Interaction between photorespi ...
Solanum tuberosum
Planta
222
130-140
2005
-
-
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1
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2
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1
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676168
Dinopoulos
Glycine decarboxylase mutation ...
Homo sapiens
Neurology
64
1255-1257
2005
-
1
1
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2
-
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-
-
-
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1
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2
-
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