BRENDA - Enzyme Database show
show all sequences of 1.4.4.2

Proteins of the glycine decarboxylase complex in the hydrogenosome of Trichomonas vaginalis

Mukherjee, M.; Brown, M.T.; McArthur, A.G.; Johnson, P.J.; Eukaryot. Cell 5, 2062-2071 (2006)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
into the pET-29B vector for expression in Escherichia coli BL21DE3 cells, into master-neo(HA)2 plasmid for transfection of Trichomonas vaginalis; pET-H1, pET-H2, and pET-L plasmids expressed in Escherichia coli BL21(DE3) cells
Trichomonas vaginalis
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0026
-
H1 protein
L protein
Trichomonas vaginalis
0.0026
-
rTvH1 protein
the apparent Km-value of rTvL for binding rTvH1
Trichomonas vaginalis
0.0037
-
H2 protein
L protein
Trichomonas vaginalis
0.0037
-
rTvH2 protein
the apparent Km-value of rTvL for binding rTvH2
Trichomonas vaginalis
0.043
-
Lipoamide
the apparent Km-value of rTvL for binding the free lipoamide
Trichomonas vaginalis
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
hydrogenosome
; H1, H2, and L protein. H and L proteins do not form a stable complex in the hydrogenosomes
Trichomonas vaginalis
42566
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
13900
-
predicted value TvH1 protein
Trichomonas vaginalis
14000
-
recombinant TvH1 protein, analysis of the native mass of TvH1 protein by gel filtration, SDS-PAGE and Western blot
Trichomonas vaginalis
14800
-
predicted value TvH2 protein
Trichomonas vaginalis
15000
-
recombinant TvH2 protein, analysis of the native mass of TvH2 protein by gel filtration, SDS-PAGE and Western blot
Trichomonas vaginalis
51800
-
predicted value TvL protein
Trichomonas vaginalis
52000
-
recombinant TvL protein, analysis of the native mass of TvL protein by gel filtration, SDS-PAGE and Western blot
Trichomonas vaginalis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
glycine + H-protein-lipoyllysine
Trichomonas vaginalis
-
H-protein-S-aminomethyldihydrolipoyllysine + CO2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Trichomonas vaginalis
-
-
-
Purification (Commentary)
Commentary
Organism
H1, H2, and L protein purified to homogeneity, more than 95% pure; using a nickel-nitrilotriacetic acid-agarose column
Trichomonas vaginalis
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
glycine + H-protein-lipoyllysine
-
673411
Trichomonas vaginalis
H-protein-S-aminomethyldihydrolipoyllysine + CO2
-
-
-
?
H1 protein
substrate for L protein
673411
Trichomonas vaginalis
?
-
-
-
?
H2 protein
substrate for L protein
673411
Trichomonas vaginalis
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
homodimer
2 * 52000, SDS-PAGE, L protein
Trichomonas vaginalis
monomer
1 * 14000, SDS-PAGE, H1 protein, 1 * 15000, SDS-PAGE, H2 protein
Trichomonas vaginalis
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
25
-
assay condition for determination of the interaction of recombinant H an L protein
Trichomonas vaginalis
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.602
-
Lipoamide
kinetic parameter for L protein
Trichomonas vaginalis
0.84
-
rTvH1 protein
kinetic parameter for L protein
Trichomonas vaginalis
2.08
-
rTvH2 protein
kinetic parameter for L protein
Trichomonas vaginalis
6.08
-
Lipoamide
kinetic parameter for L protein
Trichomonas vaginalis
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay condition for determination of the interaction of recombinant H an L protein
Trichomonas vaginalis
Cloned(Commentary) (protein specific)
Commentary
Organism
into the pET-29B vector for expression in Escherichia coli BL21DE3 cells, into master-neo(HA)2 plasmid for transfection of Trichomonas vaginalis; pET-H1, pET-H2, and pET-L plasmids expressed in Escherichia coli BL21(DE3) cells
Trichomonas vaginalis
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0026
-
H1 protein
L protein
Trichomonas vaginalis
0.0026
-
rTvH1 protein
the apparent Km-value of rTvL for binding rTvH1
Trichomonas vaginalis
0.0037
-
H2 protein
L protein
Trichomonas vaginalis
0.0037
-
rTvH2 protein
the apparent Km-value of rTvL for binding rTvH2
Trichomonas vaginalis
0.043
-
Lipoamide
the apparent Km-value of rTvL for binding the free lipoamide
Trichomonas vaginalis
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
hydrogenosome
; H1, H2, and L protein. H and L proteins do not form a stable complex in the hydrogenosomes
Trichomonas vaginalis
42566
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
13900
-
predicted value TvH1 protein
Trichomonas vaginalis
14000
-
recombinant TvH1 protein, analysis of the native mass of TvH1 protein by gel filtration, SDS-PAGE and Western blot
Trichomonas vaginalis
14800
-
predicted value TvH2 protein
Trichomonas vaginalis
15000
-
recombinant TvH2 protein, analysis of the native mass of TvH2 protein by gel filtration, SDS-PAGE and Western blot
Trichomonas vaginalis
51800
-
predicted value TvL protein
Trichomonas vaginalis
52000
-
recombinant TvL protein, analysis of the native mass of TvL protein by gel filtration, SDS-PAGE and Western blot
Trichomonas vaginalis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
glycine + H-protein-lipoyllysine
Trichomonas vaginalis
-
H-protein-S-aminomethyldihydrolipoyllysine + CO2
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
H1, H2, and L protein purified to homogeneity, more than 95% pure; using a nickel-nitrilotriacetic acid-agarose column
Trichomonas vaginalis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
glycine + H-protein-lipoyllysine
-
673411
Trichomonas vaginalis
H-protein-S-aminomethyldihydrolipoyllysine + CO2
-
-
-
?
H1 protein
substrate for L protein
673411
Trichomonas vaginalis
?
-
-
-
?
H2 protein
substrate for L protein
673411
Trichomonas vaginalis
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
homodimer
2 * 52000, SDS-PAGE, L protein
Trichomonas vaginalis
monomer
1 * 14000, SDS-PAGE, H1 protein, 1 * 15000, SDS-PAGE, H2 protein
Trichomonas vaginalis
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
25
-
assay condition for determination of the interaction of recombinant H an L protein
Trichomonas vaginalis
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.602
-
Lipoamide
kinetic parameter for L protein
Trichomonas vaginalis
0.84
-
rTvH1 protein
kinetic parameter for L protein
Trichomonas vaginalis
2.08
-
rTvH2 protein
kinetic parameter for L protein
Trichomonas vaginalis
6.08
-
Lipoamide
kinetic parameter for L protein
Trichomonas vaginalis
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay condition for determination of the interaction of recombinant H an L protein
Trichomonas vaginalis
Other publictions for EC 1.4.4.2
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741906
Go
Glycine decarboxylase is an u ...
Homo sapiens
Biochemistry
53
947-956
2014
3
-
1
-
-
-
-
5
-
1
-
1
-
2
-
-
1
1
-
-
-
-
3
2
1
-
-
7
1
-
-
1
-
-
-
3
-
1
1
-
-
-
-
-
-
5
-
1
-
1
-
-
-
1
-
-
-
-
3
2
1
-
-
7
1
-
-
-
-
1
1
-
5
5
743023
Azize
Mutation analysis of glycine ...
Homo sapiens
J. Hum. Genet.
59
593-597
2014
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
743266
Varadarajan
Plasmodium berghei glycine cl ...
no activity in Plasmodium berghei
Mol. Biochem. Parasitol.
197
50-55
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
724693
Dominy
Glycine decarboxylase cleaves ...
Mus musculus
Cancer Cell
21
143-145
2012
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
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-
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2
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1
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1
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2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
725016
Timm
Glycine decarboxylase controls ...
Arabidopsis thaliana
FEBS Lett.
586
3692-3697
2012
-
-
-
-
-
-
-
-
1
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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1
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1
-
-
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1
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1
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
724197
Zay
Glycine cleavage enzyme comple ...
Homo sapiens
Biochem. Cell Biol.
89
299-307
2011
-
-
1
-
-
-
-
-
-
-
-
1
-
5
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
725115
Zhang
-
Transcriptionally and phylogen ...
Brassica napus
Hortic. Environ. Biotechnol.
52
427-434
2011
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
-
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-
-
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1
-
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
710748
Hasse
Crystallization and preliminar ...
Synechocystis sp.
Acta Crystallogr. Sect. F
66
187-191
2010
-
-
1
1
-
-
-
-
-
-
1
1
-
4
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
713311
Palmieri
Regulation of plant glycine de ...
Arabidopsis thaliana
Plant Physiol.
152
1514-1528
2010
-
-
-
-
-
-
5
-
1
-
-
-
-
3
-
-
-
-
-
1
-
-
-
1
-
-
-
-
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5
-
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1
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-
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-
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-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
3
3
-
-
-
719865
Okamura-Ikeda
Crystal structure of aminometh ...
Escherichia coli
J. Biol. Chem.
285
18684-18692
2010
-
-
-
-
-
-
-
-
-
-
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1
-
4
-
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1
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1
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1
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697916
Hasse
Alternative splicing produces ...
Flaveria trinervia
FEBS J.
276
6985-6991
2009
-
-
1
-
-
-
-
-
1
-
-
-
-
6
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
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1
1
-
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-
-
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-
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1
-
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-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698096
Kawaguchi
Genomic organization of region ...
Gallus gallus
Gene
432
7-18
2009
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
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1
-
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-
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1
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1
-
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1
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688637
Parys
Mitochondria from leaf mesophy ...
Zea mays
J. Plant Physiol.
165
1061-1069
2008
-
-
-
-
-
-
-
-
1
-
5
-
-
6
-
-
1
-
-
2
1
-
1
1
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
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-
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1
-
5
-
-
-
-
1
-
2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689605
Engelmann
The gene for the P-subunit of ...
Flaveria trinervia
Plant Physiol.
146
1773-1785
2008
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
3
-
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1
-
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-
-
-
-
-
-
-
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-
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1
-
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-
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-
-
-
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-
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3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706478
Kikuchi
Glycine cleavage system: react ...
Escherichia coli, Gallus gallus, Gottschalkia acidurici, Homo sapiens, Peptoclostridium acidaminophilum, Pisum sativum, Thermus thermophilus
Proc. Jpn. Acad. Ser. B Phys. Biol. Sci.
84
246-263
2008
-
-
-
-
-
-
-
-
-
-
7
-
-
11
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
7
7
-
-
-
686720
Hasse
Properties of recombinant glyc ...
Synechocystis sp.
FEBS Lett.
581
1297-1301
2007
-
-
1
-
-
-
-
11
-
-
-
-
-
2
-
-
1
-
-
-
-
-
4
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
688072
Rajinikanth
The glycine decarboxylase comp ...
Populus tremuloides
J. Exp. Bot.
58
1761-1770
2007
-
-
-
-
-
-
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1
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5
-
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6
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1
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6
-
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-
689575
Engel
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391991
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391992
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Glycine metabolism. II. Kineti ...
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