Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(7-benzyloxy-2-oxo-2H-chromen-4-yl)acetonitrile | - |
Rattus norvegicus | |
(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetonitrile | - |
Rattus norvegicus | |
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N,N-dimethylacetamide | - |
Rattus norvegicus | |
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N-methylacetamide | - |
Rattus norvegicus | |
2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide | - |
Rattus norvegicus | |
2-(7-[(3-fluorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide | - |
Rattus norvegicus | |
2-(7-[(3-fluorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)propanamide | - |
Rattus norvegicus | |
2-(7-[(3-hydroxybenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide | - |
Rattus norvegicus | |
2-[2-oxo-7-(pyridin-3-ylmethoxy)-2H-chromen-4-yl]acetamide | - |
Rattus norvegicus | |
2-[2-oxo-7-(pyridin-4-ylmethoxy)-2H-chromen-4-yl]acetamide | - |
Rattus norvegicus | |
2-[7-(3-chlorobenzyloxy)-2-oxo-2H-chromen-4-yl]acetohydrazide | - |
Rattus norvegicus | |
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]-N,N-dimethylacetamide | - |
Rattus norvegicus | |
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]-N-methylacetamide | - |
Rattus norvegicus | |
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide | - |
Rattus norvegicus | |
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]acetohydrazide | - |
Rattus norvegicus | |
2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]propanamide | - |
Rattus norvegicus | |
4-(2-aminoethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one | - |
Rattus norvegicus | |
4-(aminomethyl)-7-(benzyloxy)-2H-chromen-2-one | - |
Rattus norvegicus | |
4-(aminomethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one | - |
Rattus norvegicus | |
4-([benzyl(methyl)amino]methyl)-7-[(3-chlorobenzyl)oxy]-2Hchromen-2-one | - |
Rattus norvegicus | |
4-[(benzylamino)methyl]-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one | - |
Rattus norvegicus | |
4-[(dimethylamino)methyl]-7-[(3-fluorobenzyl)oxy]-2H-chromen-2-one | - |
Rattus norvegicus | |
4-[(ethylamino)methyl]-7-[(3-fluorobenzyl)oxy]-2H-chromen-2-one methanesulfonate | - |
Rattus norvegicus | |
7-(1,3-benzodioxol-5-ylmethoxy)-4-[(methylamino)methyl]-2H-chromen-2-one | - |
Rattus norvegicus | |
7-(benzyloxy)-4-[(dimethylamino)methyl]-2H-chromen-2-one | - |
Rattus norvegicus | |
7-(benzyloxy)-4-[(methylamino)methyl]-2H-chromen-2-one | - |
Rattus norvegicus | |
7-(benzyloxy)-4-[2-(dimethylamino)ethyl]-2H-chromen-2-one | - |
Rattus norvegicus | |
7-[(3-chlorobenzyl)oxy]-4-[(dimethylamino)methyl]-2H-chromen-2-one | - |
Rattus norvegicus | |
7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one | - |
Rattus norvegicus | |
7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate | - |
Rattus norvegicus | |
7-[(3-chlorobenzyl)oxy]-4-[2-(methylamino)ethyl]-2H-chromen-2-one | - |
Rattus norvegicus | |
7-[(3-fluorobenzyl)oxy]-4-[(isopropylamino)methyl]-2H-chromen-2-one methanesulfonate | - |
Rattus norvegicus | |
7-[(3-fluorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one | - |
Rattus norvegicus | |
7-[(3-fluorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate | - |
Rattus norvegicus | |
additional information | design, synthesis, and evaluation of selective MAO-B inhibitors with favorable physicochemical and pharmacokinetic profiles, 7-[(m-halogeno)benzyloxy]coumarins bearing properly selected polar substituents at position 4, overview | Rattus norvegicus | |
N-(2-aminoethyl)-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide | - |
Rattus norvegicus | |
N-benzyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-acetamide | - |
Rattus norvegicus | |
N-butyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-acetamide | - |
Rattus norvegicus | |
N-butyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N-methylacetamide | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial outer membrane | - |
Rattus norvegicus | 5741 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Rattus norvegicus |
MAO-B | - |
Rattus norvegicus |
monoamine oxidase A | - |
Rattus norvegicus |
monoamine oxidase B | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000128 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 7-(benzyloxy)-4-[(methylamino)methyl]-2H-chromen-2-one | |
0.000013 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one | |
0.000015 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]-N-methylacetamide | |
0.000015 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 4-(aminomethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one | |
0.000016 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | (7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetonitrile | |
0.000018 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 7-[(3-fluorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one | |
0.00002 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 7-(1,3-benzodioxol-5-ylmethoxy)-4-[(methylamino)methyl]-2H-chromen-2-one | |
0.000021 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 4-(aminomethyl)-7-(benzyloxy)-2H-chromen-2-one | |
0.000024 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N-methylacetamide | |
0.00003 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide | |
0.00004 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]acetohydrazide | |
0.00004 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N,N-dimethylacetamide | |
0.00005 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 2-(7-[(3-fluorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide | |
0.00009 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 2-[7-(3-chlorobenzyloxy)-2-oxo-2H-chromen-4-yl]acetohydrazide | |
0.0001 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 4-[(ethylamino)methyl]-7-[(3-fluorobenzyl)oxy]-2H-chromen-2-one methanesulfonate | |
0.0002 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | (7-benzyloxy-2-oxo-2H-chromen-4-yl)acetonitrile | |
0.0002 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide | |
0.00023 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | (7-benzyloxy-2-oxo-2H-chromen-4-yl)acetonitrile | |
0.00025 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 4-(2-aminoethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one | |
0.0003 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 7-[(3-chlorobenzyl)oxy]-4-[2-(methylamino)ethyl]-2H-chromen-2-one | |
0.0004 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]-N,N-dimethylacetamide | |
0.00046 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 7-(benzyloxy)-4-[2-(dimethylamino)ethyl]-2H-chromen-2-one | |
0.00047 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | (7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetonitrile | |
0.0005 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N-methylacetamide | |
0.00051 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 4-[(dimethylamino)methyl]-7-[(3-fluorobenzyl)oxy]-2H-chromen-2-one | |
0.001 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 2-(7-[(3-hydroxybenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide | |
0.00112 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 7-[(3-chlorobenzyl)oxy]-4-[(dimethylamino)methyl]-2H-chromen-2-one | |
0.0013 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 2-[2-oxo-7-(pyridin-3-ylmethoxy)-2H-chromen-4-yl]acetamide | |
0.00144 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]acetohydrazide | |
0.0018 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 7-(benzyloxy)-4-[(dimethylamino)methyl]-2H-chromen-2-one | |
0.002 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 2-(7-[(3-fluorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)propanamide | |
0.002 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 4-(aminomethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one | |
0.002 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 2-[2-oxo-7-(pyridin-4-ylmethoxy)-2H-chromen-4-yl]acetamide | |
0.0025 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 2-[7-(3-chlorobenzyloxy)-2-oxo-2H-chromen-4-yl]acetohydrazide | |
0.0028 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]-N-methylacetamide | |
0.0036 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 4-[(benzylamino)methyl]-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one | |
0.0038 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 7-[(3-fluorobenzyl)oxy]-4-[(isopropylamino)methyl]-2H-chromen-2-one methanesulfonate | |
0.0043 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 2-(7-[(3-hydroxybenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide | |
0.0044 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 4-(aminomethyl)-7-(benzyloxy)-2H-chromen-2-one | |
0.005 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | N-benzyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-acetamide | |
0.0054 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 7-(1,3-benzodioxol-5-ylmethoxy)-4-[(methylamino)methyl]-2H-chromen-2-one | |
0.006 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one | |
0.0063 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]propanamide | |
0.008 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide | |
0.008 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 4-([benzyl(methyl)amino]methyl)-7-[(3-chlorobenzyl)oxy]-2Hchromen-2-one | |
0.01 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | N-(2-aminoethyl)-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide | |
0.01 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | N-butyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-acetamide | |
0.01 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | N-butyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N-methylacetamide | |
0.0135 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 7-[(3-fluorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one | |
0.0154 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 7-(benzyloxy)-4-[(methylamino)methyl]-2H-chromen-2-one | |
0.021 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 2-[2-oxo-7-(pyridin-3-ylmethoxy)-2H-chromen-4-yl]acetamide | |
0.0226 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 4-[(ethylamino)methyl]-7-[(3-fluorobenzyl)oxy]-2H-chromen-2-one methanesulfonate | |
0.0231 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]-N,N-dimethylacetamide | |
0.026 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide | |
0.026 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 7-(benzyloxy)-4-[2-(dimethylamino)ethyl]-2H-chromen-2-one | |
0.0265 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 2-[2-oxo-7-(pyridin-4-ylmethoxy)-2H-chromen-4-yl]acetamide | |
0.0318 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 4-(2-aminoethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one | |
0.0508 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 7-[(3-chlorobenzyl)oxy]-4-[(dimethylamino)methyl]-2H-chromen-2-one | |
0.07 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 2-(7-[(3-fluorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide | |
0.074 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 7-[(3-chlorobenzyl)oxy]-4-[2-(methylamino)ethyl]-2H-chromen-2-one | |
0.091 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 7-[(3-fluorobenzyl)oxy]-4-[(isopropylamino)methyl]-2H-chromen-2-one methanesulfonate | |
0.1 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | N-(2-aminoethyl)-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)acetamide | |
0.1 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | N-butyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-acetamide | |
0.1 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | N-benzyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-acetamide | |
0.1 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N,N-dimethylacetamide | |
0.1 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | N-butyl-2-(7-[(3-chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)-N-methylacetamide | |
0.1 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 4-[(benzylamino)methyl]-7-[(3-chlorobenzyl)oxy]-2H-chromen-2-one | |
0.1 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 7-(benzyloxy)-4-[(dimethylamino)methyl]-2H-chromen-2-one | |
0.1 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 4-[(dimethylamino)methyl]-7-[(3-fluorobenzyl)oxy]-2H-chromen-2-one | |
0.1 | - |
pH 7.4, temperature not specified in the publication, MAO-A | Rattus norvegicus | 4-([benzyl(methyl)amino]methyl)-7-[(3-chlorobenzyl)oxy]-2Hchromen-2-one | |
0.1 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 2-[7-(benzyloxy)-2-oxo-2H-chromen-4-yl]propanamide | |
0.1 | - |
pH 7.4, temperature not specified in the publication, MAO-B | Rattus norvegicus | 2-(7-[(3-fluorobenzyl)oxy]-2-oxo-2H-chromen-4-yl)propanamide |