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Literature summary for 1.4.3.3 extracted from

  • Subramanian, K.; Gora, A.; Spruijt, R.; Mitusinska, K.; Suarez-Diez, M.; Martins Dos Santos, V.; Schaap, P.J.
    Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access (2018), PLoS ONE, 13, e0198990 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.3

Protein Variants

Protein Variants Comment Organism
L56T increase in activity towards D-alanine, decrease in activity towards D-serine, D-tryptophan Homo sapiens
additional information mutations in residues located on the loops on the border between the active site and the secondary binding pocket. Mutations modulate substrate specificity, product egress and enzyme activity Sus scrofa
additional information mutations in residues located on the loops on the border between the active site and the secondary binding pocket. Mutations modulate substrate specificity, product egress and enzyme activity Homo sapiens
T56L decrease in activity towards D-alanine, increase in activity towards D-serine, D-tryptophan Sus scrofa
Y55A slight reduction in activity towards D-alanine, D-serine, increase in activity towards D-tryptophan, D-histidine, D-methionine, D-phenylalanine, D-tyrosine Homo sapiens
Y55A strong reduction in activity towards D-alanine, D-serine, increase in activity towards D-tryptophan, D-phenylalanine, D-tyrosine, D-arginine Sus scrofa
Y55A/L56T about 40-60% reduction in activity towards D-alanine, D-serine, slight reduction in activity towards D-tryptophan Homo sapiens
Y55A/T56L decrease in activity towards D-alanine, D-serine, increase in activity towards D-tryptophan Sus scrofa
Y55W 20-40% reduction in activity towards D-alanine, D-serine, no change in activity towards D-tryptophan Homo sapiens
Y55W strong reduction in activity towards D-alanine, D-serine, increase in activity towards D-tryptophan Sus scrofa
Y55W/L56T 50-70% reduction in activity towards D-alanine, D-serine, no change in activity towards D-tryptophan Homo sapiens
Y55W/T56L increase in activity towards D-alanine, D-tryptophan, D-arginine, D-cysteine, D-phenylalanine, D-tyrosine, decrease in activity towards D-serine Sus scrofa

Organism

Organism UniProt Comment Textmining
Homo sapiens P14920
-
-
Sus scrofa P00371
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-alanine + H2O + O2
-
 Sus scrofa pyruvate + NH3 + H2O2
-
 ?
D-alanine + H2O + O2
-
 Homo sapiens pyruvate + NH3 + H2O2
-
 ?
D-serine + H2O + O2
-
 Sus scrofa 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
D-serine + H2O + O2
-
 Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
D-tryptophan + H2O + O2
-
 Sus scrofa indol-3-pyruvate + NH3 + H2O2
-
 ?
D-tryptophan + H2O + O2
-
 Homo sapiens indol-3-pyruvate + NH3 + H2O2
-
 ?