Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
beta-aminopropionitrile | 0.4 mM, 20% inhibition | Homo sapiens | |
homocysteine | 0.03 mM, up to 50% inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.373 | - |
1,5-Diaminopentane | pH 8.2, temperature not specified in the publication | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
29000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[collagen]-L-lysine + O2 + H2O | Homo sapiens | - |
[collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28300 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,5-diaminopentane + O2 + H2O | - |
Homo sapiens | ? + NH3 + H2O2 | - |
? | |
[collagen]-L-lysine + O2 + H2O | - |
Homo sapiens | [collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LOX | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
90 | - |
the enzyme maintains its secondary structure till 90°C | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
7290 | - |
1,5-Diaminopentane | pH 8.2, temperature not specified in the publication | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8.5 | pH 7.5: about 55% of maximal activity, pH 8.5: about 85% of maximal activity | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
drug target | the enzyme is a promising therapeutic target for the progression of cancer and fibrosis | Homo sapiens |