BRENDA - Enzyme Database show
show all sequences of 1.4.3.1

D-Aspartate oxidase is present in ovaries, eggs and embryos but not in testis of Xenopus laevis

Tedeschi, G.; Negri, A.; Bernardini, G.; Oungre, E.; Ceciliani, F.; Ronchi, S.; Comp. Biochem. Physiol. B 124, 489-494 (1999)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
L-Tartrate
-
Bos taurus
L-Tartrate
at 10 mM
Xenopus laevis
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
30000
-
native PAGE
Xenopus laevis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-aspartate + H2O + O2
Bos taurus
-
oxaloacetate + NH3 + H2O2
-
-
?
D-aspartate + H2O + O2
Xenopus laevis
intermediate product is iminoaspartate
oxaloacetate + NH3 + H2O2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Xenopus laevis
-
-
-
Purification (Commentary)
Commentary
Organism
-
Xenopus laevis
expressed in Escherichia coli, mixture of 80-91% active FAD-containing and 9-20% inactive OH-FAD containing enzyme
Bos taurus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
egg
-
Xenopus laevis
-
embryo
504 hours old
Xenopus laevis
-
ovary
-
Xenopus laevis
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-aspartate + H2O + O2
-
391708
Bos taurus
oxaloacetate + NH3 + H2O2
-
-
-
?
D-aspartate + H2O + O2
-
391708
Bos taurus
oxaloacetate + NH3 + H2O2
-
391708
Bos taurus
?
D-aspartate + H2O + O2
intermediate product is iminoaspartate
391708
Xenopus laevis
oxaloacetate + NH3 + H2O2
-
-
-
?
D-aspartate + H2O + O2
intermediate product is iminoaspartate
391708
Xenopus laevis
oxaloacetate + NH3 + H2O2
-
391708
Xenopus laevis
?
Cofactor
Cofactor
Commentary
Organism
Structure
FAD
-
Xenopus laevis
FAD
-
Bos taurus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FAD
-
Xenopus laevis
FAD
-
Bos taurus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
L-Tartrate
-
Bos taurus
L-Tartrate
at 10 mM
Xenopus laevis
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
30000
-
native PAGE
Xenopus laevis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-aspartate + H2O + O2
Bos taurus
-
oxaloacetate + NH3 + H2O2
-
-
?
D-aspartate + H2O + O2
Xenopus laevis
intermediate product is iminoaspartate
oxaloacetate + NH3 + H2O2
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Xenopus laevis
expressed in Escherichia coli, mixture of 80-91% active FAD-containing and 9-20% inactive OH-FAD containing enzyme
Bos taurus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
egg
-
Xenopus laevis
-
embryo
504 hours old
Xenopus laevis
-
ovary
-
Xenopus laevis
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-aspartate + H2O + O2
-
391708
Bos taurus
oxaloacetate + NH3 + H2O2
-
-
-
?
D-aspartate + H2O + O2
-
391708
Bos taurus
oxaloacetate + NH3 + H2O2
-
391708
Bos taurus
?
D-aspartate + H2O + O2
intermediate product is iminoaspartate
391708
Xenopus laevis
oxaloacetate + NH3 + H2O2
-
-
-
?
D-aspartate + H2O + O2
intermediate product is iminoaspartate
391708
Xenopus laevis
oxaloacetate + NH3 + H2O2
-
391708
Xenopus laevis
?
Other publictions for EC 1.4.3.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742426
Florio
Tracking the evolution of epi ...
Mus musculus
Epigenetics
12
41-54
2017
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-
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1
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6
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1
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1
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6
-
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1
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-
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-
743836
Sacchi
Olanzapine, but not clozapine ...
Homo sapiens, Mus musculus
Sci. Rep.
7
46288
2017
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-
-
-
-
-
4
-
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2
-
6
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2
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2
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2
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2
4
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2
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2
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2
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742805
Takahashi
Possible role of a histidine ...
Vanrija humicola
J. Biochem.
159
371-378
2016
-
-
1
-
5
-
3
10
-
-
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1
-
3
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9
1
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10
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1
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5
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3
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10
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1
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-
-
9
1
-
-
-
10
-
-
-
-
-
-
-
-
10
10
743133
Punzo
Age-related changes in D-aspa ...
Mus musculus
J. Neurosci.
36
3064-3078
2016
-
-
-
-
-
-
-
-
-
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1
-
5
-
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1
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1
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1
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1
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1
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1
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1
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1
1
-
-
-
742035
Katane
Characterization of the enzym ...
Homo sapiens, Mus musculus, Rattus norvegicus
Biol. Pharm. Bull.
38
298-305
2015
-
-
3
-
-
-
15
3
-
1
-
3
-
9
-
-
3
-
-
1
12
-
19
-
1
-
1
3
-
1
1
3
9
-
-
-
-
3
3
-
-
-
-
15
9
3
-
1
-
3
-
-
-
3
-
1
12
-
19
-
1
-
1
3
-
1
1
-
-
-
-
-
3
3
743063
Katane
Identification of novel D-asp ...
Homo sapiens
J. Med. Chem.
58
7328-7340
2015
-
-
1
-
-
-
37
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
33
-
-
1
-
-
-
-
33
37
3
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
-
743140
Han
Changes in D-aspartic acid an ...
Mus musculus
J. Pharm. Biomed. Anal.
116
47-52
2015
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
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-
7
-
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1
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-
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-
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1
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7
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
743350
Cristino
D-aspartate oxidase influence ...
Mus musculus
Neurobiol. Aging
36
1890-1902
2015
-
-
-
-
-
-
-
-
-
-
-
1
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1
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2
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1
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1
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1
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1
1
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-
741688
Takahashi
A highly stable d-amino acid ...
no activity in Rubrobacter xylanophilus
Appl. Environ. Microbiol.
80
7219-7229
2014
-
-
-
-
-
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4
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-
-
-
-
-
-
-
723870
Senda
Crystallization and preliminar ...
Sus scrofa
Acta Crystallogr. Sect. F
68
644-646
2012
-
-
1
1
-
-
-
-
-
-
1
1
-
3
-
-
1
-
-
2
-
-
1
1
-
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-
-
-
-
-
-
-
-
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-
-
1
-
1
-
-
-
-
-
-
-
-
1
1
-
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-
1
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724597
Kato
Enzymatic assay for D-aspartic ...
Vanrija humicola
Biosci. Biotechnol. Biochem.
76
2150-2152
2012
-
-
-
-
-
-
-
2
-
-
-
1
-
3
-
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-
-
-
-
-
2
-
-
-
-
2
-
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-
1
-
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-
1
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-
-
2
-
-
-
1
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2
-
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-
2
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-
-
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-
725959
Saitoh
Spatiotemporal localization of ...
Caenorhabditis elegans, Caenorhabditis elegans N2
Mol. Cell. Biol.
32
1967-1983
2012
-
-
1
-
-
-
-
-
-
-
-
6
-
21
-
-
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-
8
-
-
6
-
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-
-
-
-
-
-
1
-
-
-
-
-
3
3
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
14
-
-
6
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-
711325
Katane
Thiolactomycin inhibits D-aspa ...
Homo sapiens, Mus musculus
Biochimie
92
1371-1378
2010
-
-
1
-
1
-
6
-
-
-
-
2
-
3
-
-
-
-
-
1
-
-
4
-
1
-
-
-
1
-
-
2
4
-
3
-
-
1
2
-
1
-
3
6
4
-
-
-
-
2
-
-
-
-
-
1
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
711718
Katane
Comparative characterization o ...
Caenorhabditis elegans
Chem. Biodivers.
7
1424-1434
2010
-
-
1
-
-
-
-
10
3
-
3
3
-
4
-
-
1
-
-
-
-
-
4
1
1
-
-
9
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
10
3
-
3
3
-
-
-
1
-
-
-
-
4
1
1
-
-
9
1
-
-
-
-
1
1
-
9
9
711719
Katane
D-aspartate oxidase: The sole ...
Bos taurus, Caenorhabditis elegans, Homo sapiens, Mus musculus, Ovis aries, Rattus norvegicus, Sus scrofa, Vanrija humicola
Chem. Biodivers.
7
1435-1449
2010
-
2
5
-
4
-
24
-
12
-
-
17
-
9
-
-
5
-
-
40
-
-
28
8
-
-
-
-
-
-
-
8
-
-
-
-
2
5
8
-
4
-
-
24
-
-
12
-
-
17
-
-
-
5
-
40
-
-
28
8
-
-
-
-
-
-
-
-
-
4
4
-
-
-
711721
Burrone
Effects of D-aspartate treatme ...
Pelophylax esculentus
Chem. Biodivers.
7
1459-1466
2010
-
-
-
-
-
-
-
-
1
-
-
1
-
3
-
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5
-
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1
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1
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1
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1
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5
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1
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1
2
2
1
-
-
711722
Topo
Thyroid hormones and D-asparti ...
Mus musculus, Rattus norvegicus
Chem. Biodivers.
7
1467-1478
2010
-
-
-
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2
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2
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5
-
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4
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2
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2
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2
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2
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2
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4
-
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2
-
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-
2
2
-
-
-
712616
di Giovanni
Distribution of free D-asparti ...
Pelophylax esculentus
J. Exp. Zool.
313 A
137-143
2010
-
-
-
-
-
-
-
10
-
-
-
3
-
5
-
-
-
-
-
5
-
-
4
-
1
-
-
-
1
1
-
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-
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-
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10
-
-
-
3
-
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5
-
-
4
-
1
-
-
-
1
1
-
-
1
1
1
1
-
-
712818
Yamamoto
D-aspartate oxidase localisati ...
Sus scrofa
J. Neuroendocrinol.
22
1165-1172
2010
-
-
-
-
-
-
-
-
1
-
-
1
-
4
-
-
-
-
-
7
-
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
7
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
712787
Takahashi
-
An active-site mutation enhanc ...
Vanrija humicola
J. Mol. Catal. B
61
235-240
2009
-
-
1
-
5
-
-
11
-
-
-
1
-
1
-
-
1
-
-
-
15
-
5
1
1
-
-
5
1
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
11
-
-
-
1
-
-
-
1
-
-
15
-
5
1
1
-
-
5
1
-
-
-
-
-
-
-
7
7
684387
Katane
Hyperactive mutants of mouse D ...
Mus musculus
Amino Acids
35
75-82
2008
-
-
1
-
3
-
-
12
-
-
-
-
-
3
-
-
1
-
-
1
12
-
2
-
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-
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1
-
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3
-
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-
12
-
-
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-
-
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-
1
-
1
12
-
2
-
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-
-
-
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-
-
-
-
-
-
-
-
-
686597
Huang
D-Aspartate and D-aspartate ox ...
Mus musculus
Exp. Eye Res.
86
704-709
2008
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673583
Katane
Caenorhabditis elegans has two ...
Caenorhabditis elegans
FEBS J.
274
137-149
2007
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17
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10
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684383
Katane
Molecular cloning of a cDNA en ...
Mus musculus
Amino Acids
32
69-78
2007
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1
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7
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687440
Yamamoto
Functional and structural char ...
Sus scrofa
J. Biochem.
141
363-376
2007
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677271
Takahashi
Physiological role of D-aspart ...
Vanrija humicola
Yeast
22
1203-1212
2005
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655928
Takahashi
Cloning and expression in Esch ...
Vanrija humicola
J. Biochem.
135
533-540
2004
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3
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6
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1
1
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2
3
1
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657350
Sarower
-
Distribution and substrate spe ...
Meretrix lusoria, Mizuhopecten yessoensis, Mytilus galloprovincialis, Octopus vulgaris, Penaeus japonicus, Procambarus clarkii, Todarodes pacificus, Turbo cornutus
Science Asia
30
335-340
2004
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8
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8
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8
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14
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16
-
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656415
Sarower
Distribution and characteristi ...
Chaunax fimbriatus, Cololabis saira, Cyprinus carpio, Dentex tumifrons, Lateolabrax japonicus, Oncorhynchus keta, Oncorhynchus masou, Oncorhynchus mykiss, Pagrus major, Paralichthys olivaceus, Plecoglossus altivelis, Pseudopleuronectes yokohamae, Sardinops melanostictus, Scomber japonicus, Thamnaconus tessellatus, Trachurus japonicus, Verasper variegatus
J. Exp. Zool. A
295
151-159
2003
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1
1
17
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17
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23
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38
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25
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1
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1
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1
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1
17
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17
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38
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25
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1
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1
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391705
Sacchi
Engineering the substrate spec ...
Bos taurus
J. Biol. Chem.
277
27510-27516
2002
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1
4
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1
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1
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4
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1
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1
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5
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391706
Zaar
Cellular and subcellular distr ...
Bos taurus, Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
J. Comp. Neurol.
450
272-282
2002
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3
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4
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166
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5
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16
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3
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5
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16
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391707
Negri
Purification of beef kidney D- ...
Bos taurus
Biochim. Biophys. Acta
1431
212-222
1999
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1
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1
10
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3
1
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3
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1
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3
1
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11
1
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1
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1
1
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1
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10
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3
1
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1
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3
1
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11
1
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-
-
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-
391708
Tedeschi
D-Aspartate oxidase is present ...
Bos taurus, Xenopus laevis
Comp. Biochem. Physiol. B
124
489-494
1999
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2
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1
2
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7
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2
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6
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2
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2
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2
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2
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6
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4
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391709
Amery
C-terminal tripeptide Ser-Asn- ...
Homo sapiens
Biochem. J.
336
367-371
1998
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1
1
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1
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2
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391710
Kera
-
D-Aspartate oxidase and free a ...
Carassius auratus langsdorfii, Cyprinus carpio, Oncorhynchus mykiss, Pagrus major, Seriola quinqueradiata
Comp. Biochem. Physiol. B
119
95-100
1998
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7
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9
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11
11
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24
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9
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11
11
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24
-
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391711
Simonic
cDNA cloning and expression of ...
Bos taurus
Biochem. J.
322
729-735
1997
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1
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2
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2
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391712
Setoyama
Structural and functional char ...
Homo sapiens
J. Biochem.
121
798-803
1997
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1
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2
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1
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1
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1
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1
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2
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4
-
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-
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-
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-
-
-
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391713
Yamada
Purification and properties of ...
Vanrija humicola, Vanrija humicola UJ1
Biochim. Biophys. Acta
1294
153-158
1996
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-
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-
-
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3
3
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1
2
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6
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1
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1
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8
1
1
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1
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1
3
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1
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3
3
3
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1
2
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1
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1
-
8
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
391714
Tedeschi
Properties of the flavoenzyme ...
Octopus vulgaris
Biochim. Biophys. Acta
1207
217-222
1994
-
-
-
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6
-
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1
1
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5
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7
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1
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1
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1
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6
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1
1
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-
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7
-
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-
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-
-
1
-
-
-
-
-
-
-
-
391715
Wakayama
-
Isolation, enzyme production a ...
Fusarium sacchari
J. Ferment. Bioeng.
78
377-379
1994
-
-
-
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1
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1
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4
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1
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1
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1
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1
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1
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1
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-
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4
-
1
-
1
-
1
-
1
-
-
-
-
-
-
-
391716
D'Aniello
Biological role of D-amino aci ...
Mus musculus, Octopus vulgaris, Rattus norvegicus
J. Biol. Chem.
268
26941-26949
1993
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3
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6
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3
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3
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6
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6
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-
-
-
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-
-
-
-
391717
D'Aniello
Further study on the specifici ...
Bos taurus, Octopus vulgaris
Comp. Biochem. Physiol. B
105
731-734
1993
-
-
-
-
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14
-
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2
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4
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-
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2
-
-
13
-
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-
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2
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-
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2
-
-
-
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-
14
-
-
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2
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-
-
2
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391718
Tedeschi
Chemical modification of funct ...
Bos taurus
Eur. J. Biochem.
205
127-132
1992
-
-
-
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-
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1
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2
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2
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3
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-
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1
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1
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1
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2
-
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3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391719
Negri
-
Structural studies of beef kid ...
Bos taurus
Flavins and Flavoproteins (Proc. Int. Symp. , 10th, Meeting Date 1990, Curti, B. , Ronchi S. , Zanetti, G. , eds. ) de Gruyter, Berlin, New York
179-187
1990
-
-
-
-
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-
2
1
-
1
1
-
1
-
-
1
-
-
1
-
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5
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
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2
1
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1
1
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1
-
1
-
-
5
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
391720
Tedeschi
-
Modification of substrate spec ...
Bos taurus
Flavins and Flavoproteins (Proc. Int. Symp. , 10th, Meeting Date 1990, Curti, B. , Ronchi S. , Zanetti, G. , eds. ) de Gruyter, Berlin, New York
189-192
1990
-
-
-
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-
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1
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1
-
1
-
-
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-
-
1
-
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6
-
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-
-
-
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-
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1
-
-
-
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-
1
-
-
-
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1
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1
-
-
-
-
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1
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391721
Negri
The kinetic mechanism of beef ...
Bos taurus
J. Biol. Chem.
263
13557-13563
1988
-
-
-
-
-
-
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2
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1
1
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2
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-
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2
-
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2
1
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-
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2
-
-
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1
-
-
-
-
-
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1
-
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-
-
-
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2
-
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1
1
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-
-
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2
-
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2
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
391722
Negri
D-Aspartate oxidase from beef ...
Bos taurus
J. Biol. Chem.
262
10026-10034
1987
-
-
-
-
-
-
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-
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1
1
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2
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1
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3
1
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2
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-
-
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1
1
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1
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3
1
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391723
Burns
Thiazolidine-2-carboxylate der ...
Bos taurus
Biochem. Biophys. Res. Commun.
125
1039-1045
1984
-
-
-
-
-
-
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4
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1
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2
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-
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2
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4
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4
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1
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2
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4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391724
Nasu
The mammalian enzyme which rep ...
Bos taurus
Biochim. Biophys. Acta
704
240-252
1982
-
-
-
-
-
-
-
-
-
-
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1
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3
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-
1
1
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2
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1
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-
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-
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1
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-
-
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-
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1
-
-
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1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391725
Rinaldi
Oxidation of meso-diaminosucci ...
Bos taurus
Eur. J. Biochem.
117
635-638
1981
-
-
-
-
-
-
-
2
-
-
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2
-
2
-
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-
-
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2
-
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3
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-
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-
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1
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1
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2
-
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-
2
-
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-
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
391726
Jaroszewicz
D-Asparatate oxidase in the th ...
Sus scrofa
Enzyme
20
80-89
1975
-
-
-
-
-
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1
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1
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1
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2
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1
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2
1
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3
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-
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1
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1
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1
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1
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1
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1
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1
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2
1
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3
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1
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391727
Dixon
D-aspartate oxidase of kidney ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
146
54-76
1967
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15
4
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1
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1
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1
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1
1
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3
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2
1
1
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2
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15
2
4
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1
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1
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1
1
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3
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2
1
1
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391728
Still
-
On the prosthetic group of the ...
Oryctolagus cuniculus, Ovis aries, Sus scrofa
J. Biol. Chem.
182
585-589
1950
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3
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3
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2
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1
6
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2
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2
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1
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3
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2
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1
6
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