Literature summary for 1.4.1.27 extracted from

Tian, S.; Feng, J.; Cao, Y.; Shen, S.; Cai, Y.; Yang, D.; Yan, R.; Wang, L.; Zhang, H.; Zhong, X.; Gao, P.
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications (2019), Life Sci. Alliance, 2, e201900413 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q91W43 and O08749	Q91W43 i.e. glycine dehydrogenase component P-protein, cf. EC 1.4.4.2, O08749 i.e. dihydrolipoyl dehydrogenase component L-protein, cf. EC 1.8.1.4	-

General Information

General Information	Comment	Organism
physiological function	the glycine cleavage system CGS is highly activated to promote stem cell pluripotency and during somatic cell reprogramming. The expression of glycine dehydrogenase GldC, regulated by Sox2 and Lin28A, facilitates this activation. The activated GCS catabolizes glycine to fuel histone H3K4me3 modification, promoting the expression of pluripotency genes. The activated GCS helps to cleave excess glycine and prevents methylglyoxal accumulation, which stimulates senescence in stem cells and during reprogramming	Mus musculus

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Release 2023.1 (January 2023)