Literature summary for 1.4.1.16 extracted from

Ma, H.; Stone, V.N.; Wang, H.; Kellogg, G.E.; Xu, P.; Zhang, Y.
Diaminopimelic acid (DAP) analogs bearing isoxazoline moiety as selective inhibitors against meso-diaminopimelate dehydrogenase (m-Ddh) from Porphyromonas gingivalis (2017), Bioorg. Med. Chem. Lett., 27, 3840-3844 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
(5S)-5-[(2S)-2-amino-2-carboxyethyl]-4,5-dihydro-1,2-oxazole-3-carboxylic acid	compound is selectively potent to Porphyromonas gingivalis strains W83 and ATCC 33277 with minimum inhibitory concentration values of 773 microM and 1.875 mM, respectively	Porphyromonas gingivalis
additional information	diastereomer (5R)-5-[(2S)-2-amino-2-carboxyethyl]-4,5-dihydro-1,2-oxazole-3-carboxylic acid has no inhibitory activity at pH 7.8	Porphyromonas gingivalis

Organism

Organism	UniProt	Comment	Textmining
Porphyromonas gingivalis	Q7MW40	-	-
Porphyromonas gingivalis W83	Q7MW40	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0149	-	pH 7.8, temperature not specified in the publication	Porphyromonas gingivalis	(5S)-5-[(2S)-2-amino-2-carboxyethyl]-4,5-dihydro-1,2-oxazole-3-carboxylic acid

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Release 2023.1 (January 2023)