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Literature summary for 1.4.1.12 extracted from

  • Stadtman, T.C.
    Lysine metyabolim by clostridia, XIIB 2,5-diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase) (1973), Adv. Enzymol. Relat. Areas Mol. Biol., 38, 441-445.
No PubMed abstract available
Search for more literature for 1.4.1.12

Inhibitors

Inhibitors Comment Organism Structure
iodoacetamide
-
 Acetoanaerobium sticklandii
organic mercurials
-
 Acetoanaerobium sticklandii
p-chloromercuribenzoate
-
 Acetoanaerobium sticklandii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.11 0.28 NADP+
-
 Acetoanaerobium sticklandii
0.6 3.3 NAD+
-
 Acetoanaerobium sticklandii
1.2 1.8 2,4-Diaminopentanoate
-
 Acetoanaerobium sticklandii
2.5
-
 2,5-Diaminohexanoate
-
 Acetoanaerobium sticklandii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000 80000 sedimentation equilibrium centrifugation Acetoanaerobium sticklandii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,4-diaminopentanoate + H2O + NAD(P)+ Acetoanaerobium sticklandii
-
 2-amino-4-oxopentanoate + NH3 + NAD(P)H
-
 r
2,4-diaminopentanoate + H2O + NAD(P)+ Clostridium sp.
-
 2-amino-4-oxopentanoate + NH3 + NAD(P)H
-
 r
2,4-diaminopentanoate + H2O + NAD(P)+ Clostridium sp. M-E SB4
-
 2-amino-4-oxopentanoate + NH3 + NAD(P)H
-
 r
2,5-diaminohexanoate + H2O + NAD(P)+ Acetoanaerobium sticklandii
-
 2-amino-5-oxohexanoate + NH3 + NAD(P)H
-
 r
2,5-diaminohexanoate + H2O + NAD(P)+ Clostridium sp.
-
 2-amino-5-oxohexanoate + NH3 + NAD(P)H
-
 r
2,5-diaminohexanoate + H2O + NAD(P)+ Clostridium sp. M-E SB4
-
 2-amino-5-oxohexanoate + NH3 + NAD(P)H
-
 r

Organism

Organism UniProt Comment Textmining
Acetoanaerobium sticklandii
-
-
-
Clostridium sp.
-
 M-E, SB4
-
Clostridium sp. M-E SB4
-
 M-E, SB4
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4-diaminopentanoate + H2O + NAD(P)+
-
 Acetoanaerobium sticklandii 2-amino-4-oxopentanoate + NH3 + NAD(P)H
-
 r
2,4-diaminopentanoate + H2O + NAD(P)+
-
 Clostridium sp. 2-amino-4-oxopentanoate + NH3 + NAD(P)H
-
 r
2,4-diaminopentanoate + H2O + NAD(P)+
-
 Clostridium sp. M-E SB4 2-amino-4-oxopentanoate + NH3 + NAD(P)H
-
 r
2,4-diaminopentanoate + H2O + NAD+
-
 Acetoanaerobium sticklandii 2-amino-4-oxopentanoate + NH3 + NADH
-
 ?
2,5-diaminohexanoate + H2O + NAD(P)+
-
 Acetoanaerobium sticklandii 2-amino-5-oxohexanoate + NH3 + NAD(P)H
-
 r
2,5-diaminohexanoate + H2O + NAD(P)+
-
 Clostridium sp. 2-amino-5-oxohexanoate + NH3 + NAD(P)H
-
 r
2,5-diaminohexanoate + H2O + NAD(P)+
-
 Acetoanaerobium sticklandii 2-amino-5-oxohexanoate + NH3 + NAD(P)H 2-amino-5-oxohexanoate cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate r
2,5-diaminohexanoate + H2O + NAD(P)+
-
 Clostridium sp. 2-amino-5-oxohexanoate + NH3 + NAD(P)H 2-amino-5-oxohexanoate cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate r
2,5-diaminohexanoate + H2O + NAD(P)+
-
 Clostridium sp. M-E SB4 2-amino-5-oxohexanoate + NH3 + NAD(P)H
-
 r
2,5-diaminohexanoate + H2O + NAD(P)+
-
 Clostridium sp. M-E SB4 2-amino-5-oxohexanoate + NH3 + NAD(P)H 2-amino-5-oxohexanoate cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate r

pH Stability

pH Stability pH Stability Maximum Comment Organism
9
-
 unstable above Acetoanaerobium sticklandii

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Acetoanaerobium sticklandii
NADP+
-
 Acetoanaerobium sticklandii