BRENDA - Enzyme Database
show all sequences of 1.4.1.1

A further characterization of alanine dehydrogenase from Streptomyces aureofaciens

Vancurova, I.; Vancura, A.; Volc, J.; Neuzil, J.; Behal, V.; J. Basic Microbiol. 29, 185-189 (1989) View publication on PubMed

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
HgCl2
-
Kitasatospora aureofaciens
L-Ala
reductive amination of pyruvate
Kitasatospora aureofaciens
L-Ser
inhibition of aminating activity
Kitasatospora aureofaciens
PCMB
-
Kitasatospora aureofaciens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
198000
-
analytical ultracentrifugation
Kitasatospora aureofaciens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
L-Ala + H2O + NAD+
Kitasatospora aureofaciens
physiological role in nitrogen metabolism in Streptomycetes
pyruvate + NH3 + NADH
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Kitasatospora aureofaciens
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
L-Ala + H2O + 1,N6-etheno-NAD+
45% of the activity with NAD+
349546
Kitasatospora aureofaciens
pyruvate + NH3 + 1,N6-etheno-NADH
-
-
-
?
L-Ala + H2O + 3-acetylpyridine-NAD+
as active as NAD+
349546
Kitasatospora aureofaciens
pyruvate + H2O + 3-acetylpyridine-NADH
-
-
-
?
L-Ala + H2O + 3-pyridinealdehyde-NAD+
5.0% of the activity with NAD+
349546
Kitasatospora aureofaciens
?
-
-
-
?
L-Ala + H2O + deamino-NAD+
90.2% of the activity with NAD+
349546
Kitasatospora aureofaciens
pyruvate + NH3 + deamino-NADH
-
-
-
?
L-Ala + H2O + NAD+
-
349546
Kitasatospora aureofaciens
pyruvate + NH3 + NADH
-
349546
Kitasatospora aureofaciens
r
L-Ala + H2O + NAD+
physiological role in nitrogen metabolism in Streptomycetes
349546
Kitasatospora aureofaciens
pyruvate + NH3 + NADH
-
-
-
?
L-Ala + H2O + nicotinamide guanine dinucleotide
59.9% of the activity with NAD+
349546
Kitasatospora aureofaciens
?
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
1,N6-etheno-NAD+
45% of the activity with NAD+
Kitasatospora aureofaciens
3-acetylpyridine-NAD+
as active as NAD+
Kitasatospora aureofaciens
3-pyridinealdehyde-NAD+
5.0% of the activity with NAD+
Kitasatospora aureofaciens
deamino-NAD+
90.2% of the activity with NAD+
Kitasatospora aureofaciens
NAD+
-
Kitasatospora aureofaciens
NADH
-
Kitasatospora aureofaciens
nicotinamide guanine dinucleotide
59.9% of the activity with NAD+
Kitasatospora aureofaciens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
1,N6-etheno-NAD+
45% of the activity with NAD+
Kitasatospora aureofaciens
3-acetylpyridine-NAD+
as active as NAD+
Kitasatospora aureofaciens
3-pyridinealdehyde-NAD+
5.0% of the activity with NAD+
Kitasatospora aureofaciens
deamino-NAD+
90.2% of the activity with NAD+
Kitasatospora aureofaciens
NAD+
-
Kitasatospora aureofaciens
NADH
-
Kitasatospora aureofaciens
nicotinamide guanine dinucleotide
59.9% of the activity with NAD+
Kitasatospora aureofaciens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
HgCl2
-
Kitasatospora aureofaciens
L-Ala
reductive amination of pyruvate
Kitasatospora aureofaciens
L-Ser
inhibition of aminating activity
Kitasatospora aureofaciens
PCMB
-
Kitasatospora aureofaciens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
198000
-
analytical ultracentrifugation
Kitasatospora aureofaciens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
L-Ala + H2O + NAD+
Kitasatospora aureofaciens
physiological role in nitrogen metabolism in Streptomycetes
pyruvate + NH3 + NADH
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
L-Ala + H2O + 1,N6-etheno-NAD+
45% of the activity with NAD+
349546
Kitasatospora aureofaciens
pyruvate + NH3 + 1,N6-etheno-NADH
-
-
-
?
L-Ala + H2O + 3-acetylpyridine-NAD+
as active as NAD+
349546
Kitasatospora aureofaciens
pyruvate + H2O + 3-acetylpyridine-NADH
-
-
-
?
L-Ala + H2O + 3-pyridinealdehyde-NAD+
5.0% of the activity with NAD+
349546
Kitasatospora aureofaciens
?
-
-
-
?
L-Ala + H2O + deamino-NAD+
90.2% of the activity with NAD+
349546
Kitasatospora aureofaciens
pyruvate + NH3 + deamino-NADH
-
-
-
?
L-Ala + H2O + NAD+
-
349546
Kitasatospora aureofaciens
pyruvate + NH3 + NADH
-
349546
Kitasatospora aureofaciens
r
L-Ala + H2O + NAD+
physiological role in nitrogen metabolism in Streptomycetes
349546
Kitasatospora aureofaciens
pyruvate + NH3 + NADH
-
-
-
?
L-Ala + H2O + nicotinamide guanine dinucleotide
59.9% of the activity with NAD+
349546
Kitasatospora aureofaciens
?
-
-
-
?
Other publictions for EC 1.4.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Protein Variants
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
kcat/KM [mM/s]
kcat/KM [mM/s] (protein specific)
741751
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1
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2
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9
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1
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2
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4
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10
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2
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8
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2
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1
1
2
-
4
-
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-
8
-
-
-
-
-
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-
-
-
-
-
2
-
-
-
-
8
-
-
-
-
-
-
-
-
8
8
743605
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11
e0155522
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-
-
-
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11
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-
1
1
1
1
-
-
742450
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Eur. J. Med. Chem.
92
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-
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4
2
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-
-
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10
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
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-
-
4
-
-
-
-
-
-
-
4
4
-
2
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-
2
-
-
-
-
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11
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1
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1
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2
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2
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15
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2
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1
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2
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2
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-
-
15
-
-
-
-
2
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-
-
-
-
-
-
-
20
20
743120
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-
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13
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3
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1
1
-
-
-
-
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-
1
2
-
9
-
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1
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-
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2
1
1
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-
2
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1
2
1
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1
2
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1
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2
1
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741520
Wen
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69
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-
-
1
1
-
-
-
-
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1
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7
-
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1
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1
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1
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1
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742778
Jeong
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195
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6
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1
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1
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743765
Zech
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Phaeobacter inhibens, Phaeobacter inhibens DSM 17395
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13
2869-2885
2013
-
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3
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1
1
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725267
Giffin
ald of Mycobacterium tuberculo ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Bacteriol.
194
1045-1054
2012
-
-
1
-
1
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-
6
3
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6
-
191
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1
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1
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6
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1
1
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1
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2
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1
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3
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6
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6
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1
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1
2
2
1
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724147
Al-Onazi
-
Isolation and characterization ...
Thielaviopsis paradoxa
Asian J. Appl. Sci.
4
702-711
2011
2
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3
5
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7
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1
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1
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1
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7
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1
1
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712264
Nakane
-
Coimmobilization of malic enzy ...
Geobacillus stearothermophilus
J. Appl. Polym. Sci.
116
2901-2905
2010
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712305
Pernil
Catabolic function of compartm ...
Anabaena sp., Anabaena sp. PCC 7120
J. Bacteriol.
192
5165-5172
2010
-
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1
-
1
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2
-
30
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2
1
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2
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1
1
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1
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1
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2
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1
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2
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1
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1
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2
2
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-
705545
Ye
Heterologous expression of the ...
Bacillus subtilis, no activity in Lactococcus lactis, Bacillus subtilis natto
Microbiol. Res.
165
268-275
2009
-
1
1
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-
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-
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1
2
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21
-
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1
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2
1
1
1
1
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1
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1
1
1
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1
2
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1
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2
1
1
1
-
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-
-
-
-
-
-
-
-
-
-
705546
Ye
Heterologous expression of the ...
Bacillus subtilis
Microbiol. Res.
165
268-775
2009
-
1
1
-
-
-
-
-
-
-
2
-
-
19
-
-
1
-
-
-
2
-
1
-
2
2
-
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-
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1
-
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1
1
1
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2
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1
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2
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1
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2
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688401
Agren
Three-dimensional structures o ...
Mycobacterium tuberculosis
J. Mol. Biol.
377
1161-1173
2008
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1
1
3
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2
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1
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4
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1
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1
2
1
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2
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1
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1
1
1
3
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1
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1
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1
2
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2
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Alanine production in an H+-AT ...
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Production of L-alanine by met ...
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Alanine dehydrogenase activity ...
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Contribution of L-alanine dehy ...
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Markerless mutagenesis in Meth ...
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A novel archaeal alanine dehyd ...
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Regulation of L-alanine dehydr ...
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Structure of alanine dehydroge ...
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Ashida
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Conversion of cofactor specifi ...
Shewanella sp., Phormidium lapideum, Phormidium lapideum Ac10, Shewanella sp. Ac10
J. Mol. Catal. B
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2004
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14
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Smith
Crystallization and phasing of ...
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655519
Irwin
Alanine dehydrogenase from the ...
Shewanella sp., Shewanella sp. PA-43
Extremophiles
7
135-143
2003
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1
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19
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Bae
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Purification and biochemical c ...
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2003
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Kato
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Purification and characterizat ...
Vibrio proteolyticus
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373-378
2003
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349591
Feng
Mycobacterium smegmatis L-Alan ...
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2002
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349592
Vadas
Room-temperature synthesis of ...
Archaeoglobus fulgidus
Biotechnol. Prog.
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2002
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1
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1
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349594
Usha
Glycine and alanine dehydrogen ...
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Baysal
Screening and simple purificat ...
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277-285
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2
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349584
Irwin
Characterization of alanine an ...
Vibrio proteolyticus, Bacteria, Phormidium lapideum, Shewanella sp.
Extremophiles
5
199-211
2001
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1
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349581
Laue
Purification, properties and p ...
Bilophila wadsworthia
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2
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349583
Allaway
Identification of alanine dehy ...
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Hutter
Properties of the 40 kDa antig ...
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349593
Galkin
Cold-adapted alanine dehydroge ...
Vibrio proteolyticus, Geobacillus stearothermophilus, Bacillus subtilis, Carnobacterium sp., Shewanella sp., Carnobacterium sp. St2, Shewanella sp. Ac10
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3
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Hutter
Host vector system for high-le ...
Mycobacterium tuberculosis
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Sedelnikova
Crystallization of the alanine ...
Phormidium lapideum
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1998
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Kim
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Unusual allosteric property of ...
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Chowdhury
Alanine dehydrogenase from Ent ...
Klebsiella aerogenes
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11
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1
1
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1
1
11
2
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2
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2
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1
6
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1
6
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4
-
4
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3
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1
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1
1
11
2
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2
-
2
-
1
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349587
Delforge
Identification of lysine 74 in ...
Bacillus subtilis
J. Biol. Chem.
272
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1997
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6
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1
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349563
Sawa
Purification and characterizat ...
Bacillus subtilis, Phormidium lapideum
J. Biochem.
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995-1000
1994
1
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-
1
14
5
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2
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12
-
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1
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1
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5
2
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1
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2
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2
2
1
4
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1
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4
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1
-
14
-
5
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2
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1
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1
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5
2
1
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2
-
2
2
1
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349599
Brunhuber
The biochemistry and enzymolog ...
Anabaena cylindrica, Geobacillus stearothermophilus, Bacillus cereus, Bacillus subtilis, Bacillus japonicum, Bacillus licheniformis, Lysinibacillus sphaericus, Thermus thermophilus, Halobacterium salinarum, Mycobacterium tuberculosis, Pseudomonas sp., Kitasatospora aureofaciens
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1994
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12
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19
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24
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24
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8
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42
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1
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12
-
-
-
-
-
19
-
-
-
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349586
Smith
Alanine dehydrogenase from soy ...
Rhizobium sp.
Arch. Biochem. Biophys.
304
379-385
1993
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-
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7
5
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6
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1
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4
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4
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1
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349597
Siranosian
Alanine dehydrogenase (ald) is ...
Bacillus subtilis
J. Bacteriol.
175
6789-6796
1993
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2
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349536
Sakamoto
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Gene cloning, purification and ...
Geobacillus stearothermophilus
J. Ferment. Bioeng.
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154-158
1990
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2
1
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1
1
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1
1
10
1
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3
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2
2
1
2
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1
2
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4
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2
1
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1
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1
1
10
1
-
-
3
-
2
2
1
-
-
-
-
-
-
-
349537
Ohshima
Thermostable alanine dehydroge ...
Lysinibacillus sphaericus
Eur. J. Biochem.
191
715-720
1990
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-
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3
6
5
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2
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1
6
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1
1
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1
1
6
1
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3
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1
2
1
2
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2
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3
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6
-
5
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2
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1
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1
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1
1
6
1
-
-
3
-
1
2
1
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-
-
-
-
-
-
349538
Glasfeld
The stereospecificities of sev ...
Acholeplasma laidlawii
J. Biol. Chem.
265
11692-11699
1990
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-
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1
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1
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349539
Honorat
-
Synthesis of L-alanine and L-v ...
Priestia megaterium
Enzyme Microb. Technol.
12
515-520
1990
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4
3
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8
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2
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8
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1
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1
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2
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349540
Schultz
Enzymes of ammonia assimilatio ...
Frankia sp.
J. Bacteriol.
172
1380-1384
1990
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1
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2
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349543
Kuroda
Alanine dehydrogenases from tw ...
Geobacillus stearothermophilus, Lysinibacillus sphaericus
Biochemistry
29
1009-1015
1990
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1
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3
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7
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2
3
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2
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4
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1
4
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3
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1
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2
3
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2
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349541
El-Awamry
Partial purification and prope ...
Cunninghamella elegans
Zentralbl. Mikrobiol.
144
231-240
1989
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2
3
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6
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1
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2
1
1
1
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1
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1
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2
2
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2
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2
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2
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3
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5
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1
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2
1
1
1
-
1
-
1
-
2
2
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349542
Flores
-
Ammonium-assimilating enzymes ...
Saccharopolyspora erythraea
J. Gen. Appl. Microbiol.
35
203-211
1989
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4
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349544
Ohshima
Continous production of 3-fluo ...
Lysinibacillus sphaericus
Biotechnol. Bioeng.
34
394-397
1989
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1
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2
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349545
Caballero
Purification and properties of ...
Rhodobacter capsulatus
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1989
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2
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3
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5
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5
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1
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1
2
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1
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349546
Vancurova
A further characterization of ...
Kitasatospora aureofaciens
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185-189
1989
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7
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7
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1
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7
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349547
Vancura
Alanine dehydrogenase from Str ...
Streptomyces fradiae
Eur. J. Biochem.
179
221-227
1989
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7
7
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2
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1
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1
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7
1
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1
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6
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6
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7
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7
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2
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1
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1
2
7
1
1
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2
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349596
Hutter B; Dick T
Increased alanine dehydrogenas ...
Mycolicibacterium smegmatis
FEMS Microbiol. Lett.
167
7-11
1989
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2
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349548
Vancurova
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Purification and partial chara ...
Kitasatospora aureofaciens
Arch. Microbiol.
150
438-440
1988
-
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5
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2
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1
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1
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1
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1
1
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1
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3
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3
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5
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2
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1
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1
-
1
1
1
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-
2
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-
-
-
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-
-
349549
Weiss
Use of primary deuterium and 1 ...
Bacillus subtilis
Biochemistry
27
4814-4822
1988
-
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1
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1
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-
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-
6015
Crow
Properties of alanine dehydrog ...
Propionibacterium freudenreichii
Appl. Environ. Microbiol.
53
1885-1892
1987
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-
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3
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1
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4
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1
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1
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1
1
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2
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2
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4
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1
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1
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1
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2
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1
1
-
-
-
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349551
Bellion
An NAD+-dependent alanine dehy ...
Pseudomonas sp., Pseudomonas sp. MA
Biochem. J.
244
565-570
1987
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-
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7
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1
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1
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4
1
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1
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2
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2
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7
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2
2
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1
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1
-
4
1
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1
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-
-
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-
-
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349552
Porumb
Structural and catalytic prope ...
Bacillus cereus
J. Biol. Chem.
262
4610-4615
1987
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1
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8
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1
-
1
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-
1
1
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-
2
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2
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-
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-
-
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2
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-
1
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2
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1
1
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-
1
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
349553
Stams
-
Metabolism of L-alanine in Des ...
Desulfotomaculum ruminis, Desulfovibrio sp.
Arch. Microbiol.
145
277-279
1986
-
-
-
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2
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2
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-
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-
-
-
-
2
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4
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4
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2
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2
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
349554
Ohshima
-
Screening of thermostable leuc ...
Geobacillus stearothermophilus, Bacillus coagulans, Bacillus sp. (in: Bacteria), Lysinibacillus sphaericus
Biotechnol. Lett.
7
871-876
1985
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-
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4
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9
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8
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8
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-
-
4
-
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-
9
-
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-
-
-
-
-
-
-
-
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349556
Itoh
-
Crystallization and properties ...
Streptomyces phaeochromogenes, Bacillus subtilis, Lysinibacillus sphaericus, Streptomyces flaveus, Micromonospora melanosporea, Streptomyces bobili, Streptomyces olivochromogenes, Streptomyces roseochromogenus, Kitasatospora albolonga, Streptomyces albus, Streptomyces aureus, Streptomyces caespitosus, Streptomyces clavuligerus, Streptomyces coelicolor, Streptomyces griseoluteus, Streptomyces griseus, Streptomyces hygroscopicus, Streptomyces lydicus, Streptomyces roseus, Streptomyces ruber
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1983
6
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1
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7
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20
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1
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1
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36
3
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1
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7
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2
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1
42
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6
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42
1
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12
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7
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2
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1
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1
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36
3
1
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7
-
2
-
1
-
-
-
-
-
-
-
349557
Bellion
-
Nitrogen assimilation in facul ...
Pseudomonas sp., Pseudomonas sp. MA, Pseudomonas sp. AM1
Curr. Microbiol.
9
37-44
1983
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-
-
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16
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3
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2
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2
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-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349558
Lauwers
Thermal properties of enzymes ...
[Bacillus] caldolyticus, Anoxybacillus flavithermus
Antonie van Leeuwenhoek
49
191-201
1983
-
-
-
-
-
-
-
-
-
-
-
-
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2
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-
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2
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3
1
3
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4
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4
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-
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-
-
-
2
-
3
1
3
-
-
-
-
-
-
-
-
-
-
-
349565
Muresan
Catalytic properties of Sephar ...
Bacillus cereus
Biochim. Biophys. Acta
742
617-622
1983
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349566
Mueller
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Alanine dehydrogenase from bac ...
Anabaena cylindrica, Bradyrhizobium japonicum
Z. Naturforsch. C
37
927-936
1982
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349567
Tolxdorff-Neutzling
-
Metabolic role and regulation ...
Rhodobacter capsulatus
FEMS Microbiol. Lett.
13
155-159
1982
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349559
Grimshaw
Kinetic mechanism of Bacillus ...
Bacillus subtilis
Biochemistry
20
5650-5655
1981
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349560
Grimshaw
Use of isotope effects and pH ...
Bacillus subtilis
Biochemistry
20
5655-5661
1981
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349568
Vali
L-Alanine dehydrogenase from T ...
Bacillus subtilis, Thermus thermophilus
Biochim. Biophys. Acta
615
34-47
1980
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349569
Keradjopoulos
Salt-dependent conformational ...
Halobacterium salinarum
FEBS Lett.
112
183-185
1980
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349570
Aharonowitz
Alanine dehydrogenase of the b ...
Streptomyces clavuligerus
Arch. Microbiol.
125
137-142
1980
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13
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349571
Keradjopoulos
Purification and properties of ...
Halobacterium salinarum
Biochim. Biophys. Acta
570
1-10
1979
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349572
Ohashima
Purification and properties of ...
Lysinibacillus sphaericus
Eur. J. Biochem.
100
29-39
1979
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349573
Kim
Partial purification and prope ...
Halobacterium salinarum
Biochem. J.
161
313-320
1977
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349580
Keradjopoulos
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Thermophilic character of enzy ...
Bacillus cereus, Bacillus subtilis, Halobacterium salinarum, Bacillus cereus T
FEMS Microbiol. Lett.
1
179-182
1977
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349574
Rowell
Alanine dehydrogenase of the N ...
Anabaena cylindrica
Arch. Microbiol.
107
115-124
1976
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349562
Alizade
Stereochemistry of the hydroge ...
Bacillus subtilis
Biochim. Biophys. Acta
397
5-8
1975
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12940
Nitta
L-Amino acid dehydrogenases in ...
Bacillus subtilis
J. Bacteriol.
117
588-592
1974
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349576
Keradjopoulos
Thermophilic alanine dehydroge ...
Halobacterium salinarum
Can. J. Biochem.
52
1033-1037
1974
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349577
McCowen
Regulation of alanine dehydrog ...
Bacillus licheniformis
J. Bacteriol.
118
590-597
1974
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349578
Graefe
Activity of alanine dehydrogen ...
Streptomyces hygroscopicus
Z. Allg. Mikrobiol.
14
181-192
1974
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349585
Williamson
-
L-Alanin ...
Bacillus subtilis
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
2
1724-1727
1974
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349564
Sulzman
Characterization of circadian ...
Euglena gracilis, Euglena gracilis Z
Biochim. Biophys. Acta
320
594-609
1973
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349579
Borris
Relationship of L-alanine and ...
Bacillus thuringiensis
Biochim. Biophys. Acta
191
716-718
1969
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349561
Germano
Purification and properties of ...
Desulfovibrio desulfuricans
J. Bacteriol.
96
55-60
1968
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349598
Berberich
-
D-Amino acids as inducers of L ...
Bacillus subtilis
J. Biol. Chem.
243
1008-1013
1968
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349555
Yoshida
Enzymic properties of Alanine ...
Bacillus subtilis
Biochim. Biophys. Acta
96
248-262
1965
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18
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18
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10
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