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Literature summary for 1.3.5.2 extracted from
- Analysis of the kinetic mechanism of the bovine liver mitochondrial dihydroorotate dehydrogenase (1989), Biochemistry, 28, 1222-1226.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Barbituric acid | - |
Bos taurus |  |
| Orotate | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.009 | - |
dihydroorotate | - |
Bos taurus | |
| 0.0092 | - |
S-dihydroorotate | - |
Bos taurus | |
| 0.014 | - |
coenzyme Q6 | - |
Bos taurus | |
| 0.0142 | - |
coenzyme Q6 | - |
Bos taurus | |
| 0.0154 | - |
methyl dihydroorotate | - |
Bos taurus | |
| 0.1542 | - |
methyl dihydroorotate | - |
Bos taurus | |
| 0.184 | - |
menadione | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Bos taurus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Iron | iron-sulfur center | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| (S)-dihydroorotate + a quinone = orotate + a quinol | ping-pong mechanism | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-dihydroorotate + menadione | - |
Bos taurus | orotate + menadiol | - |
r | |
| (S)-dihydroorotate + ubiquinone | - |
Bos taurus | orotate + ubiquinol | - |
? | |
| dihydroorotate + acceptor | acceptor: coenzyme Q6 | Bos taurus | orotate + reduced acceptor | - |
? | |
| dihydroorotate + acceptor | acceptor: menadione | Bos taurus | orotate + reduced acceptor | - |
? | |
| L-dihydroorotate + ubiquinone-6 | - |
Bos taurus | orotate + reduced ubiquinone-6 | - |
? | |
| methyl-dihydroorotate + acceptor | - |
Bos taurus | methyl-orotate + reduced acceptor | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 18.3 | - |
menadione | - |
Bos taurus | |
| 44.2 | - |
coenzyme Q6 | - |
Bos taurus | |
| 45.4 | - |
methyl-dihydroorotate | - |
Bos taurus | |
| 50.4 | - |
dihydroorotate | - |
Bos taurus | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FMN | - |
Bos taurus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.005 | - |
Orotic acid | competitive to dihydroorotate | Bos taurus | |
| 0.092 | - |
Barbiturate | - |
Bos taurus | |
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