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Literature summary for 1.3.1.9 extracted from

  • Khan, R.; Zeb, A.; Choi, K.; Lee, G.; Lee, K.; Lee, S.
    Biochemical and structural insights concerning triclosan resistance in a novel YX7K type enoyl-acyl carrier protein reductase from soil metagenome (2019), Sci. Rep., 9, 15401 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.9

Crystallization (Commentary)

Crystallization (Comment) Organism
homology modeling of structure uncultured bacterium

Protein Variants

Protein Variants Comment Organism
A128V mutation elevates triclosan resistance uncultured bacterium

Inhibitors

Inhibitors Comment Organism Structure
triclosan triclosan may occupy the active site of FabI2 and form stable interactions with active catalytic residues. Mild resistance (20 microg/ml minimum inhibitory concentration) of FabI2 to triclosan is confined to the relatively less bulky side chain of A128. Substitution of A128 in FabI2 with valine elevates triclosan resistance uncultured bacterium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0138
-
 crotonoyl-CoA pH 7, 25°C uncultured bacterium
0.0182
-
 NADH pH 7, 25°C uncultured bacterium

Organism

Organism UniProt Comment Textmining
uncultured bacterium A0A1C9H9U9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
crotonoyl-CoA + NADH + H+
-
 uncultured bacterium butanoyl-CoA + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
FabI2
-
 uncultured bacterium
OsmC
-
 uncultured bacterium

General Information

General Information Comment Organism
metabolism FabI2 possesses a YX7K type catalytic domain uncultured bacterium