Literature summary for 1.3.1.83 extracted from

Meadows, C.; Mingardon, F.; Garabedian, B.; Baidoo, E.; Benites, V.; Rodrigues, A.; Abourjeily, R.; Chanal, A.; Lee, T.
Discovery of novel geranylgeranyl reductases and characterization of their substrate promiscuity (2018), Biotechnol. Biofuels, 11, 340 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Sulfolobus acidocaldarius
expressed in Escherichia coli BL21(DE3) cells	Thermoplasma acidophilum
expressed in Escherichia coli BL21(DE3) cells	Streptomyces coelicolor
expressed in Escherichia coli BL21(DE3) cells	Methanocaldococcus infernus
expressed in Escherichia coli BL21(DE3) cells	Thermococcus nautili
expressed in Escherichia coli BL21(DE3) cells	Archaeoglobus fulgidus
expressed in Escherichia coli BL21(DE3) cells	Pyrolobus fumarii
expressed in Escherichia coli BL21(DE3) cells	Methanosarcina acetivorans

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
geranylgeranyl diphosphate + 3 NADPH + 3 H+	Sulfolobus acidocaldarius	-	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	Thermoplasma acidophilum	-	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	Streptomyces coelicolor	-	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	Methanocaldococcus infernus	-	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	Thermococcus nautili	-	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	Archaeoglobus fulgidus	-	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	Pyrolobus fumarii	-	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	Methanosarcina acetivorans	-	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	Pyrolobus fumarii DSM 11204	-	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	Methanosarcina acetivorans DSM 2834	-	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	Archaeoglobus fulgidus DSM 8774	-	phytyl diphosphate + 3 NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Archaeoglobus fulgidus	A0A075WDX8	-	-
Archaeoglobus fulgidus DSM 8774	A0A075WDX8	-	-
Methanocaldococcus infernus	-	-	-
Methanosarcina acetivorans	Q8TSV3	-	-
Methanosarcina acetivorans DSM 2834	Q8TSV3	-	-
Pyrolobus fumarii	G0EHJ8	-	-
Pyrolobus fumarii DSM 11204	G0EHJ8	-	-
Streptomyces coelicolor	-	-	-
Sulfolobus acidocaldarius	-	-	-
Thermococcus nautili	-	-	-
Thermoplasma acidophilum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
geranylgeranyl diphosphate + 3 NADPH + 3 H+	-	Sulfolobus acidocaldarius	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	-	Thermoplasma acidophilum	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	-	Streptomyces coelicolor	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	-	Methanocaldococcus infernus	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	-	Thermococcus nautili	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	-	Archaeoglobus fulgidus	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	-	Pyrolobus fumarii	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	-	Methanosarcina acetivorans	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	-	Pyrolobus fumarii DSM 11204	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	-	Methanosarcina acetivorans DSM 2834	phytyl diphosphate + 3 NADP+	-	?
geranylgeranyl diphosphate + 3 NADPH + 3 H+	-	Archaeoglobus fulgidus DSM 8774	phytyl diphosphate + 3 NADP+	-	?

Subunits

Subunits	Comment	Organism
?	x * 45000, calculated from amino acid sequence	Thermoplasma acidophilum
?	x * 45000, calculated from amino acid sequence	Methanocaldococcus infernus
?	x * 45000, calculated from amino acid sequence	Methanosarcina acetivorans
?	x * 46000, calculated from amino acid sequence	Thermococcus nautili
?	x * 47000, calculated from amino acid sequence	Streptomyces coelicolor
?	x * 53000, calculated from amino acid sequence	Pyrolobus fumarii
?	x * 52000, calculated from amino acid sequence	Sulfolobus acidocaldarius

Synonyms

Synonyms	Comment	Organism
geranylgeranyl reductase	-	Sulfolobus acidocaldarius
geranylgeranyl reductase	-	Thermoplasma acidophilum
geranylgeranyl reductase	-	Streptomyces coelicolor
geranylgeranyl reductase	-	Methanocaldococcus infernus
geranylgeranyl reductase	-	Thermococcus nautili
geranylgeranyl reductase	-	Archaeoglobus fulgidus
geranylgeranyl reductase	-	Pyrolobus fumarii
geranylgeranyl reductase	-	Methanosarcina acetivorans
GGR	-	Sulfolobus acidocaldarius
GGR	-	Thermoplasma acidophilum
GGR	-	Streptomyces coelicolor
GGR	-	Methanocaldococcus infernus
GGR	-	Thermococcus nautili
GGR	-	Archaeoglobus fulgidus
GGR	-	Pyrolobus fumarii
GGR	-	Methanosarcina acetivorans

Cofactor

Cofactor	Comment	Organism	Structure
flavin	-	Sulfolobus acidocaldarius
flavin	-	Thermoplasma acidophilum
flavin	-	Streptomyces coelicolor
flavin	-	Methanocaldococcus infernus
flavin	-	Thermococcus nautili
flavin	-	Archaeoglobus fulgidus
flavin	-	Pyrolobus fumarii
flavin	-	Methanosarcina acetivorans

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Release 2023.1 (January 2023)