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Literature summary for 1.3.1.24 extracted from

  • Gordon, D.M.; Adeosun, S.O.; Ngwudike, S.I.; Anderson, C.D.; Hall, J.E.; Hinds, T.D.; Stec, D.E.
    CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation (2019), Arch. Biochem. Biophys., 672, 108072 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
pharmacology critical role for biliverdin reductase A in protecting against lipid accumulation and oxidative stress in hepatocytes which may serve as a future therapeutic target for non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH) Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q9CY64
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-

Source Tissue

Source Tissue Comment Organism Textmining
Hepa-1c1c7 cell
-
 Mus musculus
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liver
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 Mus musculus
-

Synonyms

Synonyms Comment Organism
biliverdin reductase A
-
 Mus musculus
BVRA
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 Mus musculus

General Information

General Information Comment Organism
malfunction the loss of biliverdin reductase A results in the reduction of mitochondria number, decreased expression of markers of mitochondrial biogenesis, uncoupling, oxidation, and fusion, which paralleles reduced mitochondrial oxygen consumption. Biliverdin reductase A KO cells exhibit increased levels of ROS generation and decreased levels of superoxide dismutase mRNA expression Mus musculus
metabolism critical role for biliverdin reductase A in protecting against lipid accumulation and oxidative stress in hepatocytes which may serve as a future therapeutic target for non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH) Mus musculus