Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bisdemethoxycurcumin | 22.2% inhibition at 0.3 mM | Homo sapiens | |
curcumin | complete inhibition at 0.3 mM | Homo sapiens | |
demethoxycurcumin | complete inhibition at 0.3 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
testosterone + NADPH + H+ | Homo sapiens | - |
5alpha-dihydrotestosterone + NADP+ | - |
? | |
testosterone + NADPH + H+ | Homo sapiens CRL-1740 | - |
5alpha-dihydrotestosterone + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens CRL-1740 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LNCaP cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
testosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-dihydrotestosterone + NADP+ | - |
? | |
testosterone + NADPH + H+ | - |
Homo sapiens CRL-1740 | 5alpha-dihydrotestosterone + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
S5alphaR | - |
Homo sapiens |
steroid 5-alpha reductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0134 | - |
at pH 7.4 and 37°C | Homo sapiens | curcumin | |
0.0225 | - |
at pH 7.4 and 37°C | Homo sapiens | demethoxycurcumin | |
0.3 | - |
at pH 7.4 and 37°C | Homo sapiens | bisdemethoxycurcumin |