Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3 20-dione | - |
Homo sapiens | |
17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3 20-dione | - |
Mesocricetus auratus | |
17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3,20-dione | - |
Homo sapiens | |
17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3,20-dione | - |
Mesocricetus auratus | |
17alpha-phenylcarbamoyloxy-4-pregnen-3,20-dione | - |
Homo sapiens | |
17alpha-phenylcarbamoyloxy-4-pregnen-3,20-dione | - |
Mesocricetus auratus | |
dutasteride | - |
Homo sapiens | |
dutasteride | - |
Mesocricetus auratus | |
finasteride | - |
Homo sapiens | |
finasteride | - |
Mesocricetus auratus | |
turosteride | - |
Homo sapiens | |
turosteride | - |
Mesocricetus auratus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Mesocricetus auratus | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mesocricetus auratus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate gland | - |
Homo sapiens | - |
prostate gland | - |
Mesocricetus auratus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
testosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-dihydrotestosterone + NADP+ | - |
? | |
testosterone + NADPH + H+ | - |
Mesocricetus auratus | 5alpha-dihydrotestosterone + NADP+ | - |
? | |
testosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-dihydrotestosterone + NADP+ + H+ | - |
? | |
testosterone + NADPH + H+ | - |
Mesocricetus auratus | 5alpha-dihydrotestosterone + NADP+ + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
steroid 5alpha-reductase | - |
Homo sapiens |
steroid 5alpha-reductase | - |
Mesocricetus auratus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Mesocricetus auratus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000085 | - |
in the presence of 1 mM dithiothreitol, in 40 mM sodium phosphate buffer, at pH 6.5 | Homo sapiens | finasteride | |
0.0000085 | - |
with 1 mM dithiothreitol in 40 mM sodium phosphate buffer, at pH 6.5 and 37°C | Homo sapiens | finasteride | |
0.00001 | - |
in the presence of 1 mM dithiothreitol, in 40 mM sodium phosphate buffer, at pH 6.5 | Homo sapiens | 17alpha-phenylcarbamoyloxy-4-pregnen-3,20-dione | |
0.00001 | - |
with 1 mM dithiothreitol in 40 mM sodium phosphate buffer, at pH 6.5 and 37°C | Homo sapiens | 17alpha-phenylcarbamoyloxy-4-pregnen-3,20-dione | |
0.00005 | - |
in the presence of 1 mM dithiothreitol, in 40 mM sodium phosphate buffer, at pH 6.5 | Homo sapiens | 17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3 20-dione | |
0.00005 | - |
with 1 mM dithiothreitol in 40 mM sodium phosphate buffer, at pH 6.5 and 37°C | Homo sapiens | 17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3,20-dione |