BRENDA - Enzyme Database
show all sequences of 1.3.1.13

Non-plastidic, tyrosine-insensitive prephenate dehydrogenases from legumes

Schenck, C.A.; Chen, S.; Siehl, D.L.; Maeda, H.A.; Nat. Chem. Biol. 11, 52-57 (2015)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
not inhibited by L-Tyr
Glycine max
additional information
not inhibited by L-Tyr
Medicago truncatula
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.127
-
prephenate
at 37°C, pH not specified in the publication
Glycine max
0.223
-
prephenate
at 37°C, pH not specified in the publication
Medicago truncatula
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
prephenate + NADP+
Glycine max
-
4-hydroxyphenylpyruvate + CO2 + NADPH
-
-
?
prephenate + NADP+
Medicago truncatula
-
4-hydroxyphenylpyruvate + CO2 + NADPH
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Glycine max
-
-
-
Medicago truncatula
-
-
-
no activity in Arabidopsis thaliana
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
leaf
-
Glycine max
-
leaf
-
Medicago truncatula
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
prephenate + NADP+
-
741040
Glycine max
4-hydroxyphenylpyruvate + CO2 + NADPH
-
-
-
?
prephenate + NADP+
-
741040
Medicago truncatula
4-hydroxyphenylpyruvate + CO2 + NADPH
-
-
-
?
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
21.8
-
prephenate
at 37°C, pH not specified in the publication
Medicago truncatula
26.3
-
prephenate
at 37°C, pH not specified in the publication
Glycine max
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
-
Glycine max
NADP+
-
Medicago truncatula
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
-
Glycine max
NADP+
-
Medicago truncatula
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
not inhibited by L-Tyr
Glycine max
additional information
not inhibited by L-Tyr
Medicago truncatula
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.127
-
prephenate
at 37°C, pH not specified in the publication
Glycine max
0.223
-
prephenate
at 37°C, pH not specified in the publication
Medicago truncatula
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
prephenate + NADP+
Glycine max
-
4-hydroxyphenylpyruvate + CO2 + NADPH
-
-
?
prephenate + NADP+
Medicago truncatula
-
4-hydroxyphenylpyruvate + CO2 + NADPH
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
leaf
-
Glycine max
-
leaf
-
Medicago truncatula
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
prephenate + NADP+
-
741040
Glycine max
4-hydroxyphenylpyruvate + CO2 + NADPH
-
-
-
?
prephenate + NADP+
-
741040
Medicago truncatula
4-hydroxyphenylpyruvate + CO2 + NADPH
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
21.8
-
prephenate
at 37°C, pH not specified in the publication
Medicago truncatula
26.3
-
prephenate
at 37°C, pH not specified in the publication
Glycine max
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
100
-
prephenate
at 37°C, pH not specified in the publication
Medicago truncatula
217
-
prephenate
at 37°C, pH not specified in the publication
Glycine max
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
100
-
prephenate
at 37°C, pH not specified in the publication
Medicago truncatula
217
-
prephenate
at 37°C, pH not specified in the publication
Glycine max
Other publictions for EC 1.3.1.13
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740113
Shlaifer
Biochemical characterization o ...
Ignicoccus hospitalis
Biochim. Biophys. Acta
1865
312-320
2017
-
-
1
-
-
-
1
1
-
-
-
2
-
1
-
-
1
-
-
-
-
-
2
1
-
-
1
1
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
1
-
1
-
-
-
2
-
-
-
1
-
-
-
-
2
1
-
-
1
1
-
-
-
-
-
-
-
-
1
1
740420
Shlaifer
Characterization of two key en ...
Ignicoccus hospitalis, Nanoarchaeum equitans
Extremophiles
20
503-514
2016
-
-
2
-
-
-
2
8
-
-
2
4
-
7
-
-
2
-
-
-
-
-
4
2
2
-
2
-
-
-
-
4
-
-
-
-
-
2
4
-
-
-
-
2
-
8
-
-
2
4
-
-
-
2
-
-
-
-
4
2
2
-
2
-
-
-
-
-
-
-
-
-
-
-
741040
Schenck
Non-plastidic, tyrosine-insens ...
Glycine max, Medicago truncatula, no activity in Arabidopsis thaliana
Nat. Chem. Biol.
11
52-57
2015
-
-
-
-
-
-
2
2
-
-
-
2
-
3
-
-
-
-
-
2
-
-
2
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
2
-
2
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
390560
Byng
Evolutionary implications of f ...
Acinetobacter calcoaceticus, Acinetobacter lwoffii, Acinetobacter sp., Acinetobacter sp. C1W
Arch. Microbiol.
143
122-129
1985
-
-
-
-
-
-
2
2
-
-
1
4
-
4
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
1
-
-
-
-
2
2
2
-
-
1
4
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390525
Waldner-Sander
Zur Biosynthese von Phenylalan ...
Flavobacterium sp.
Hoppe-Seyler's Z. Physiol. Chem.
364
1467-1473
1983
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390558
Hall
Biochemical diversity for bios ...
Anabaena sp., Fischerella sp., Lyngbya sp., no activity in Anabaena sp., no activity in Calothrix sp., no activity in Nostoc sp., no activity in Scytonema sp. 29171, no activity in Scytonema sp., no activity in Synechocystis sp., Nostoc sp., Synechococcus sp., Synechocystis sp.
J. Bacteriol.
149
65-78
1982
-
-
-
-
-
-
1
-
-
-
-
6
-
12
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
5
-
-
-
-
1
-
-
-
-
-
6
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390557
Rubin
Enzymology of L-tyrosine biosy ...
Burkholderia cepacia, Comamonas testosteroni, Pseudomonas alkanolytica, Vigna radiata
Plant Physiol.
64
727-734
1979
-
-
-
-
-
-
2
3
1
-
1
2
-
4
-
-
1
-
-
1
1
-
2
-
-
-
1
-
1
-
-
3
-
-
-
-
-
-
3
-
-
-
-
2
-
3
1
-
1
2
-
-
-
1
-
1
1
-
2
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
390556
Gamborg
Aromatic metabolism in plants ...
Klebsiella aerogenes, no activity in Beta vulgaris subsp. vulgaris, no activity in Oryza sativa, no activity in Pisum sativum, no activity in Triticum aestivum, Phaseolus coccineus, Phaseolus vulgaris, Vicia faba, Vigna radiata
Biochim. Biophys. Acta
115
65-72
1966
-
-
-
-
-
-
2
4
-
-
-
5
-
9
-
-
1
-
-
6
-
-
5
-
-
-
-
-
2
1
1
1
-
-
-
-
-
-
1
-
-
-
-
2
-
4
-
-
-
5
-
-
-
1
-
6
-
-
5
-
-
-
-
-
2
1
1
-
-
-
-
-
-
-