Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.124 extracted from

  • De Nys, K.; Meyhi, E.; Mannaerts, G.P.; Fransen, M.; Van Veldhoven, P.P.
    Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase (2001), Biochim. Biophys. Acta, 1533, 66-72 .
    View publication on PubMed
Search for more literature for 1.3.1.124

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.006
-
 (2E,4E)-2,4-decadienoyl-CoA presence of 0.1% albumin, pH 7.4, 30°C Homo sapiens
0.059
-
 (2E,4E)-2,4-hexadienoyl-CoA presence of 0.1% albumin, pH 7.4, 30°C Homo sapiens
0.102
-
 2,4,7,10,13,16,19-docosaheptaenoyl-CoA absence of albumin, pH 7.4, 30°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Homo sapiens 5777
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NUI1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,4E)-2,4-decadienoyl-CoA + NADPH + H+ preferred substrate Homo sapiens (3E)-deca-3-enoyl-CoA + NADP+
-
 ?
(2E,4E)-2,4-hexadienoyl-CoA + NADPH + H+
-
 Homo sapiens (3E)-hexa-3-enoyl-CoA + NADP+
-
 ?
2,4,7,10,13,16,19-docosaheptaenoyl-CoA + NADPH + H+
-
 Homo sapiens (3E)-3,7,10,13,16,19-docosahexaenoyl-CoA + NADP+
-
 ?

Subunits

Subunits Comment Organism
? x * 30778, calculated from sequence Homo sapiens

Synonyms

Synonyms Comment Organism
DECR2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the reductase does not seem to constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. The reduction of docosaheptaenoyl-CoA is severely decreased in the presence of albumin Homo sapiens