BRENDA - Enzyme Database show
show all sequences of 1.3.1.12

Evolution of the biochemical pathway for aromatic amino acid biosynthesis in Serpens flexibilis in relationship to its phylogenetic position

Ahmad, S.; Jensen, R.A.; Arch. Microbiol. 147, 8-12 (1987)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
4-hydroxymercuribenzoate
-
Pseudomonas flexibilis
L-tyrosine
-
Pseudomonas flexibilis
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.045
0.09
prephenate
-
Pseudomonas flexibilis
0.45
-
NAD+
-
Pseudomonas flexibilis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
prephenate + NAD+
Pseudomonas flexibilis
biosynthesis of L-tyrosine
4-hydroxyphenylpyruvate + NADH + CO2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Pseudomonas flexibilis
-
-
-
Purification (Commentary)
Commentary
Organism
copurification with arogenate dehydrogenase
Pseudomonas flexibilis
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
prephenate + NAD+
-
390548
Pseudomonas flexibilis
4-hydroxyphenylpyruvate + NADH + CO2
-
-
-
?
prephenate + NAD+
biosynthesis of L-tyrosine
390548
Pseudomonas flexibilis
4-hydroxyphenylpyruvate + NADH + CO2
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
additional information
NADP+ cannot substitute for NAD+
Pseudomonas flexibilis
NAD+
-
Pseudomonas flexibilis
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.017
-
L-tyrosine
with prephenate as variable substrate
Pseudomonas flexibilis
0.02
-
L-tyrosine
with NAD+ as variable substrate
Pseudomonas flexibilis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
additional information
NADP+ cannot substitute for NAD+
Pseudomonas flexibilis
NAD+
-
Pseudomonas flexibilis
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
4-hydroxymercuribenzoate
-
Pseudomonas flexibilis
L-tyrosine
-
Pseudomonas flexibilis
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.017
-
L-tyrosine
with prephenate as variable substrate
Pseudomonas flexibilis
0.02
-
L-tyrosine
with NAD+ as variable substrate
Pseudomonas flexibilis
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.045
0.09
prephenate
-
Pseudomonas flexibilis
0.45
-
NAD+
-
Pseudomonas flexibilis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
prephenate + NAD+
Pseudomonas flexibilis
biosynthesis of L-tyrosine
4-hydroxyphenylpyruvate + NADH + CO2
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
copurification with arogenate dehydrogenase
Pseudomonas flexibilis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
prephenate + NAD+
-
390548
Pseudomonas flexibilis
4-hydroxyphenylpyruvate + NADH + CO2
-
-
-
?
prephenate + NAD+
biosynthesis of L-tyrosine
390548
Pseudomonas flexibilis
4-hydroxyphenylpyruvate + NADH + CO2
-
-
-
?
Other publictions for EC 1.3.1.12
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746929
Lopez-Nieves
Biochemical characterization ...
Pleurotus ostreatus, Saccharomyces cerevisiae
Arch. Biochem. Biophys.
665
12-19
2019
-
-
2
-
2
-
2
2
-
-
-
2
-
9
-
-
2
-
-
-
4
-
6
-
-
-
-
2
-
-
-
3
-
-
-
-
-
2
3
-
2
-
-
2
-
2
-
-
-
2
-
-
-
2
-
-
4
-
6
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
740113
Shlaifer
Biochemical characterization o ...
Haemophilus influenzae, Haemophilus influenzae RD KW20
Biochim. Biophys. Acta
1865
312-320
2017
-
-
1
-
-
-
1
1
-
-
-
2
-
7
-
-
1
-
-
-
-
-
2
1
-
-
1
1
-
-
-
1
-
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-
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-
1
1
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-
-
-
1
-
1
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-
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2
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1
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-
-
-
2
1
-
-
1
1
-
-
-
-
-
-
-
-
1
1
723959
Jiang
Identification of a metagenome ...
uncultured bacterium
Antonie van Leeuwenhoek
103
1209-1219
2013
-
-
1
-
-
-
1
1
-
4
1
1
-
3
-
-
1
-
-
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1
1
1
1
-
1
1
1
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
1
-
4
1
1
-
-
-
1
-
-
-
-
1
1
1
1
-
1
1
1
-
1
-
-
-
-
1
1
725144
Ku
Crystal structure of prephenat ...
Streptococcus mutans, Streptococcus mutans ATCC 700610
Int. J. Biol. Macromol.
49
761-766
2011
-
-
1
1
-
-
-
-
-
-
-
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-
7
-
-
-
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-
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1
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1
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-
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-
710738
Chiu
The structure of Haemophilus i ...
Haemophilus influenzae, Haemophilus influenzae KW20
Acta Crystallogr. Sect. F
66
1317-1325
2010
-
-
1
1
-
-
1
-
-
-
-
2
-
6
-
-
1
-
-
-
-
-
6
1
-
-
-
-
-
-
-
1
-
-
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-
1
1
1
-
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-
1
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2
-
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-
1
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-
6
1
-
-
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-
-
1
1
-
-
-
726409
Ku
-
Expression and functional char ...
Streptococcus mutans, Streptococcus mutans ATCC 700610
Process Biochem.
45
607-612
2010
-
-
1
-
-
-
2
2
-
-
3
-
-
3
-
-
1
-
-
-
1
1
2
1
1
-
-
2
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
2
-
-
3
-
-
-
-
1
-
-
1
1
2
1
1
-
-
2
1
1
-
-
-
-
-
-
2
2
692260
Lim
Characterization of a key trif ...
Archaeoglobus fulgidus
Extremophiles
13
191-198
2009
-
-
1
-
-
-
2
2
-
-
3
1
-
6
-
-
1
-
-
-
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2
1
1
-
-
-
-
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1
-
-
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1
1
-
-
-
-
2
-
2
-
-
3
1
-
-
-
1
-
-
-
-
2
1
1
-
-
-
-
-
-
-
-
1
1
-
1
1
698889
Sun
The crystal structure of Aquif ...
Aquifex aeolicus
J. Biol. Chem.
284
13223-13232
2009
-
-
-
1
5
-
1
11
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
10
-
-
-
1
3
-
-
-
-
-
1
1
5
-
-
1
3
11
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
684578
Chavez-Bejar
Metabolic engineering of Esche ...
Zymomonas mobilis
Appl. Environ. Microbiol.
74
3284-3290
2008
-
-
1
-
-
-
1
-
-
-
-
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1
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1
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1
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1
1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
685716
Patnaik
L-tyrosine production by recom ...
Escherichia coli
Biotechnol. Bioeng.
99
741-752
2008
-
-
-
-
-
-
-
-
-
-
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1
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1
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1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684595
Olson
Production of tyrosine from su ...
Escherichia coli
Appl. Microbiol. Biotechnol.
74
1031-1040
2007
-
-
-
-
-
-
-
-
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1
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1
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1
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1
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1
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-
674545
Sun
Crystal structure of prephenat ...
Aquifex aeolicus
J. Biol. Chem.
281
12919-12928
2006
-
-
1
1
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
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-
1
-
-
-
-
-
1
1
1
1
-
-
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-
1
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-
1
1
-
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-
-
-
-
-
-
-
-
676965
Xu
Purification and characterizat ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Protein Expr. Purif.
49
151-158
2006
-
1
1
-
-
-
1
2
-
-
2
-
-
165
-
-
1
-
-
-
-
-
2
-
1
-
-
2
1
-
-
-
-
-
1
-
1
1
-
-
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-
1
1
-
2
-
-
2
-
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-
1
-
-
-
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2
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
677010
Bonvin
Biochemical characterization o ...
Aquifex aeolicus
Protein Sci.
15
1417-1432
2006
1
-
1
-
1
-
3
18
-
1
2
-
-
4
-
-
1
-
-
-
-
1
2
1
1
1
-
18
1
-
-
-
-
-
-
1
-
1
-
-
1
-
-
3
-
18
-
1
2
-
-
-
-
1
-
-
-
1
2
1
1
1
-
18
1
-
-
-
-
-
-
-
-
-
671431
Luetke-Eversloh
Feedback inhibition of chorism ...
Escherichia coli, Escherichia coli K-12 MG1655
Appl. Environ. Microbiol.
71
7224-7228
2005
-
-
1
-
1
-
1
-
-
-
-
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-
5
-
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1
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1
-
2
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1
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1
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2
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-
655472
Chen
Mapping of chorismate mutase a ...
Escherichia coli
Eur. J. Biochem.
270
757-763
2003
-
-
1
-
-
-
1
1
-
-
-
1
-
2
-
1
1
1
-
-
4
1
2
2
1
-
-
-
1
-
-
1
-
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-
-
1
1
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1
-
1
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1
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1
1
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-
4
1
2
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
654967
Vincent
Probing the overlap of chorism ...
Escherichia coli
Bioorg. Med. Chem. Lett.
12
929-931
2002
-
-
-
-
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-
8
-
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1
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2
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1
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2
-
1
-
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1
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1
9
-
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1
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-
8
9
-
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1
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2
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1
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1
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-
390553
Christendat
Identifying groups Involved in ...
Escherichia coli
Biochemistry
38
4782-4793
1999
-
-
1
-
1
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4
-
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1
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2
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2
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4
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1
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1
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4
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2
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4
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390554
Kishore
-
A thermodynamic investigation ...
Pantoea agglomerans
J. Chem. Thermodyn.
31
211-227
1999
-
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1
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1
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1
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2
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1
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2
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390552
Christendat
Use of site-directed mutagenes ...
Escherichia coli
Biochemistry
37
15703-15712
1998
-
-
1
-
5
-
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4
-
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1
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1
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1
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1
1
2
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6
-
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1
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5
-
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4
-
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1
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1
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1
1
2
-
-
-
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6
-
-
-
-
-
-
-
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-
-
390555
Christopherson
Partial inactivation of choris ...
Escherichia coli
Int. J. Biochem. Cell Biol.
29
589-594
1997
-
-
-
-
-
-
2
-
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2
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1
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2
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1
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390551
Fischer
-
Clues from a halophilic methan ...
Methanohalophilus mahii
Arch. Microbiol.
160
440-446
1993
-
-
-
-
-
-
2
4
-
-
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-
1
-
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-
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2
-
1
1
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-
1
1
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2
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2
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2
-
4
-
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-
-
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2
-
1
1
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1
1
-
-
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-
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-
390511
Speth
Terminal phenylalanine and tyr ...
Microtetraspora glauca
Biol. Chem. Hoppe-Seyler
370
591-599
1989
-
-
-
-
-
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2
-
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1
1
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1
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1
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2
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2
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390515
Mannhaupt
Characterization of the prephe ...
Saccharomyces cerevisiae
Gene
85
303-311
1989
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1
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1
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2
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3557
Davidson
Chorismate mutase-prephenate d ...
Escherichia coli
Methods Enzymol.
142
440-450
1987
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-
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-
4
3
2
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1
1
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1
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1
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4
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1
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1
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1
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2
1
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390512
Berry
Enzymic arrangement and allost ...
Neisseria gonorrhoeae
Arch. Microbiol.
149
87-94
1987
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2
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1
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2
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1
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2
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390513
Fischer
Prephenate dehydrogenase (mono ...
Bacillus subtilis, Cupriavidus necator, Xanthomonas campestris
Methods Enzymol.
142
503-507
1987
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-
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7
3
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3
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1
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1
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6
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2
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7
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3
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3
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1
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6
-
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390516
Maruya
Genetic separability of the ch ...
Escherichia coli
J. Bacteriol.
169
4852-4853
1987
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2
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390517
Berry
Enzymological features of arom ...
Acholeplasma laidlawii, Acholeplasma laidlawii JA1, Mycoplasma gallinarum, Mycoplasma iowae
J. Gen. Microbiol.
133
2147-2154
1987
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8
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2
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1
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8
-
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390518
Ahmad
The prephenate dehydrogenase c ...
Escherichia coli, Klebsiella pneumoniae
FEBS Lett.
216
133-139
1987
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2
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2
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5
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6
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4
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2
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6
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390519
Hund
-
Phenylalanine and tyrosine bio ...
no activity in Actinomycetales
Z. Naturforsch. C
42
387-393
1987
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390548
Ahmad
-
Evolution of the biochemical p ...
Pseudomonas flexibilis
Arch. Microbiol.
147
8-12
1987
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2
2
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2
2
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2
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2
2
2
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1
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1
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2
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390549
Byng
-
Evolution of aromatic biosynth ...
Azomonas insignis
Arch. Microbiol.
144
222-227
1986
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1
2
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2
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1
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2
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33876
Bode
-
Regulation of chorismate mutas ...
Candida maltosa
J. Basic Microbiol.
25
291-298
1985
2
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2
2
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1
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2
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390521
Christopherson
Chorismate mutase-prephenate d ...
Escherichia coli
Biochemistry
24
1116-1121
1985
2
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-
2
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1
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2
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2
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390522
Hudson
Chorismate mutase/prephenate d ...
Escherichia coli
Biochemistry
23
6240-6249
1984
-
-
-
-
-
2
4
2
-
-
1
1
-
1
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-
1
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1
1
2
1
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1
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2
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4
-
2
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1
1
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1
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1
1
2
1
-
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-
1
-
-
-
-
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-
390523
Hermes
Mechanisms of enzymatic and ac ...
Escherichia coli
Biochemistry
23
6263-6275
1984
-
-
-
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1
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2
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1
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2
-
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390546
Hudson
Nucleotide sequence and transc ...
Escherichia coli
J. Mol. Biol.
180
1023-1051
1984
-
-
-
-
-
-
-
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1
1
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1
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1
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2
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390524
Christopherson
Chorismate mutase-prephenate d ...
Escherichia coli
Biochemistry
22
1650-1656
1983
-
-
-
-
-
-
6
-
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1
-
2
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1
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2
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6
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1
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1
-
2
-
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-
-
-
-
-
-
-
-
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-
-
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390525
Waldner-Sander
Zur Biosynthese von Phenylalan ...
Novosphingobium capsulatum, Sphingomonas paucimobilis
Hoppe-Seyler's Z. Physiol. Chem.
364
1467-1473
1983
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-
-
-
-
-
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2
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4
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4
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2
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2
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-
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-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
390526
Hudson
The binding of tyrosine and NA ...
Escherichia coli
J. Biol. Chem.
258
3114-3120
1983
-
-
-
-
-
-
1
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2
1
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1
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2
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1
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2
1
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-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390527
Bhosale
Production of chorismate mutas ...
Escherichia coli
Biochim. Biophys. Acta
717
6-11
1982
-
-
1
-
-
-
-
-
-
-
1
1
-
1
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1
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1
2
2
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-
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-
1
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-
-
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1
1
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1
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1
2
2
-
-
-
-
-
-
-
-
-
-
-
-
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-
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390528
Sampathkumar
Chorismate mutase-prephenate d ...
Escherichia coli
Biochim. Biophys. Acta
702
204-211
1982
-
-
-
-
-
-
-
-
-
-
1
1
-
1
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1
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-
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1
2
1
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-
-
-
-
-
-
-
-
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-
-
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-
-
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-
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-
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1
1
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1
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1
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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390529
Sampathkumar
Chorismate mutase-prephenate d ...
Escherichia coli
Biochim. Biophys. Acta
702
212-219
1982
1
-
-
-
-
-
3
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1
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2
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-
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2
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1
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3
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1
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-
2
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
390530
Llewellyn
-
Study of chorismate mutase-pre ...
Escherichia coli
Biochemistry
18
4707-4714
1979
-
-
-
-
-
5
-
1
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-
2
1
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1
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-
-
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-
-
2
-
-
-
-
-
-
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-
-
-
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-
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5
-
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1
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2
1
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
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-
-
-
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390531
Fazel
Obligatory biosynthesis of L-t ...
no activity in coryneform bacteria
J. Bacteriol.
138
805-815
1979
-
-
-
-
-
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-
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5
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-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390545
Heyde
Chorismate mutase-prephenate d ...
Klebsiella aerogenes
Biochemistry
18
2766-2775
1979
-
-
-
-
-
-
1
-
-
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1
-
1
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-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
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-
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-
1
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-
1
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
390544
Heyde
Kinetic studies on the reactio ...
Klebsiella aerogenes
Biochemistry
17
1573-1580
1978
1
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-
-
-
1
4
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1
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2
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1
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-
1
1
2
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-
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-
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-
1
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-
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-
1
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4
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-
1
-
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1
-
-
1
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390532
Smith
Affinity chromatography and in ...
Escherichia coli
Biochem. J.
165
121-126
1977
-
-
-
-
-
-
4
-
-
-
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1
-
1
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1
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1
-
2
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-
-
-
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-
-
-
-
-
-
-
-
-
-
-
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4
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-
1
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1
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-
1
-
2
-
-
-
-
-
-
-
-
-
-
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-
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390547
Patel
Dual enzymatic routes to L-tyr ...
Pseudomonas aeruginosa
J. Biol. Chem.
252
5839-5846
1977
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-
-
-
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1
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1
1
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1
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1
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-
-
-
2
-
-
-
-
-
-
-
-
2
1
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-
-
-
-
2
-
-
-
-
1
1
-
-
-
1
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
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3542
Friedrich
Purification and properties of ...
Cupriavidus necator
J. Bacteriol.
126
712-722
1976
-
-
-
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1
4
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1
1
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3
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1
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-
-
2
1
2
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-
-
-
-
-
-
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-
-
-
-
-
-
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1
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4
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1
1
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1
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-
2
1
2
-
-
-
-
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-
-
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33883
Friedrich
Regulation of Chorismate mutas ...
Cupriavidus necator
J. Bacteriol.
126
723-732
1976
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2
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2
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1
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-
1
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-
4
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-
-
-
-
-
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5
4
2
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-
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1
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-
-
-
-
-
2
-
1
-
-
-
1
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-
-
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390535
Stenmark-Cox
Prephenate dehydrogenase from ...
Pseudomonas aeruginosa
Arch. Biochem. Biophys.
167
540-546
1975
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-
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1
1
1
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1
1
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2
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1
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-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
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1
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1
1
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1
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2
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33885
Hagino
-
Regulatory properties of preph ...
Corynebacterium glutamicum
Agric. Biol. Chem.
38
2367-2376
1974
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1
1
1
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1
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1
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2
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1
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1
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1
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1
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1
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1
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2
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1
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1
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390537
Koch
Studies on the relationship be ...
Escherichia coli, Klebsiella aerogenes
Biochim. Biophys. Acta
258
719-730
1972
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-
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7
2
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2
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2
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2
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4
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7
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2
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2
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2
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4
-
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390539
Koch
The purification and character ...
Escherichia coli
Biochim. Biophys. Acta
229
795-804
1971
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-
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4
1
2
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1
1
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1
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1
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1
2
2
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1
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4
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1
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2
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1
1
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1
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1
2
2
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1
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390540
Koch
Characterisation of the subuni ...
Escherichia coli
Biochim. Biophys. Acta
229
805-812
1971
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-
-
-
-
-
-
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1
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1
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2
1
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1
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2
1
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390538
Dayan
-
Determination of prephenate de ...
Escherichia coli, Salmonella sp.
Methods Enzymol.
17A
562-563
1970
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2
-
2
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2
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4
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2
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2
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4
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390541
Koch
Studies on the subunit structu ...
Klebsiella aerogenes
Biochim. Biophys. Acta
212
387-395
1970
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-
-
-
-
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1
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1
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2
1
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1
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2
1
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390542
Koch
Tyrosine biosynthesis in Aerob ...
Klebsiella aerogenes
Biochim. Biophys. Acta
212
375-386
1970
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-
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2
2
2
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1
1
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1
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1
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1
1
2
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1
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2
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2
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2
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1
1
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1
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1
1
2
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1
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390550
Champney
The enzymology of prephenate d ...
Bacillus subtilis
J. Biol. Chem.
245
3763-3770
1970
-
-
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5
2
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1
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1
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2
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1
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2
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1
1
1
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1
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2
5
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2
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5
5
2
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1
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1
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1
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2
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1
1
1
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1
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390543
Catheside
-
Prephenate dehydrogenase from ...
Neurospora sp.
Biochem. Biophys. Res. Commun.
367
651-656
1969
1
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1
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1
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