KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Homo sapiens | |
additional information | - |
additional information | - |
Rattus norvegicus | |
additional information | - |
additional information | - |
Platyrrhini | |
0.0000055 | - |
3,3',5-triiodo-L-thyronine | - |
Rattus norvegicus | |
0.000037 | - |
L-thyroxine | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Lithobates catesbeianus | - |
- |
microsome | isozyme type III | Gallus gallus | - |
- |
microsome | isozyme type III | Homo sapiens | - |
- |
microsome | isozyme type III | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | 5-deiodinase activity in brain is slightly decreased in hypo- and slightly increased in hyperthyroidism | ? | - |
? | |
additional information | Gallus gallus | isozyme type III is a oncofetal enzyme, regulation | ? | - |
? | |
additional information | Homo sapiens | isozyme type III is a oncofetal enzyme, regulation | ? | - |
? | |
additional information | Rattus norvegicus | isozyme type III is a oncofetal enzyme, regulation | ? | - |
? | |
additional information | Lithobates catesbeianus | isozyme type III is a oncofetal enzyme, regulation | ? | - |
? | |
additional information | Platyrrhini | isozyme type III is a oncofetal enzyme, regulation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
isozyme type III | - |
Homo sapiens | - |
isozyme type III | - |
Lithobates catesbeianus | - |
isozyme type III | - |
Lithobates catesbeianus | - |
tadpole | - |
Platyrrhini | - |
isozyme type III | - |
Rattus norvegicus | - |
isozyme type III | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | isozyme type III | Gallus gallus | - |
brain | isozyme type III | Homo sapiens | - |
brain | isozyme type III | Rattus norvegicus | - |
cerebral cortex | isozyme type III | Rattus norvegicus | - |
colon carcinoma cell | isozyme type III | Homo sapiens | - |
hepatocarcinoma cell | isozyme type III | Platyrrhini | - |
intestine | fetal | Rattus norvegicus | - |
intestine | isozyme type III | Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | embryonic | Gallus gallus | - |
liver | isozyme type III | Gallus gallus | - |
liver | tadpole | Lithobates catesbeianus | - |
placenta | isozyme type III | Homo sapiens | - |
placenta | isozyme type III | Rattus norvegicus | - |
skin | isozyme type III | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5-triiodo-L-thyronine + AH2 | - |
Platyrrhini | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodo-L-thyronine + AH2 | best substrate | Gallus gallus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodo-L-thyronine + AH2 | best substrate | Homo sapiens | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodo-L-thyronine + AH2 | best substrate | Rattus norvegicus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodo-L-thyronine + AH2 | best substrate | Lithobates catesbeianus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodo-L-thyronine + AH2 | isozyme type III | Gallus gallus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodo-L-thyronine + AH2 | isozyme type III | Homo sapiens | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodo-L-thyronine + AH2 | isozyme type III | Rattus norvegicus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodo-L-thyronine + AH2 | isozyme type III | Lithobates catesbeianus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | preferred substrate | Gallus gallus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | preferred substrate | Homo sapiens | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | preferred substrate | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | preferred substrate | Lithobates catesbeianus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | preferred substrate | Platyrrhini | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | isozyme type III | Gallus gallus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | isozyme type III | Homo sapiens | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | isozyme type III | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | isozyme type III | Lithobates catesbeianus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | isozyme type III | Platyrrhini | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | 5-deiodinase activity | Gallus gallus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | 5-deiodinase activity | Homo sapiens | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | 5-deiodinase activity | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | 5-deiodinase activity | Lithobates catesbeianus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | 5-deiodinase activity | Platyrrhini | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
additional information | isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions | Gallus gallus | ? | - |
? | |
additional information | isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions | Homo sapiens | ? | - |
? | |
additional information | isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions | Rattus norvegicus | ? | - |
? | |
additional information | isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions | Lithobates catesbeianus | ? | - |
? | |
additional information | isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions | Platyrrhini | ? | - |
? | |
additional information | 5-deiodinase activity in brain is slightly decreased in hypo- and slightly increased in hyperthyroidism | Rattus norvegicus | ? | - |
? | |
additional information | isozyme type III is a oncofetal enzyme, regulation | Gallus gallus | ? | - |
? | |
additional information | isozyme type III is a oncofetal enzyme, regulation | Homo sapiens | ? | - |
? | |
additional information | isozyme type III is a oncofetal enzyme, regulation | Rattus norvegicus | ? | - |
? | |
additional information | isozyme type III is a oncofetal enzyme, regulation | Lithobates catesbeianus | ? | - |
? | |
additional information | isozyme type III is a oncofetal enzyme, regulation | Platyrrhini | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | cofactor, influences the kinetic parameters | Gallus gallus | |
dithiothreitol | cofactor, influences the kinetic parameters | Homo sapiens | |
dithiothreitol | cofactor, influences the kinetic parameters | Rattus norvegicus | |
dithiothreitol | cofactor, influences the kinetic parameters | Lithobates catesbeianus | |
dithiothreitol | cofactor, influences the kinetic parameters | Platyrrhini | |
dithiothreitol | i.e. DTT | Gallus gallus | |
dithiothreitol | i.e. DTT | Homo sapiens | |
dithiothreitol | i.e. DTT | Rattus norvegicus | |
dithiothreitol | i.e. DTT | Lithobates catesbeianus | |
dithiothreitol | i.e. DTT | Platyrrhini | |
dithiothreitol | optimal at 50-100 mM | Gallus gallus | |
dithiothreitol | optimal at 50-100 mM | Homo sapiens | |
dithiothreitol | optimal at 50-100 mM | Rattus norvegicus | |
dithiothreitol | optimal at 50-100 mM | Lithobates catesbeianus | |
dithiothreitol | optimal at 50-100 mM | Platyrrhini |