Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
nucleus | - |
Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q02218 | - |
- |
Mus musculus | Q60597 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HAP-1 cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | histone H2A.Z-bound chromatin is associated with metabolic enzymes, oxoglutarate dehydrogenase (OGDH) and acetyl-CoA acyltransferase 2 (ACAA2) in the nucleus. OGDH and ACAA2 predominantly associate with H2A.Z-occupied transcription start sites and enhancers | Mus musculus |
physiological function | histone H2A.Z-deficient human HAP1 cells exhibit reduced chromatin-bound metabolic enzymes, accompanied with reduced posttranslational histone modifications, including acetylation and succinylation. Knockdown of OGDH diminishes histone H4 succinylation | Homo sapiens |