Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
cytoplasm | isoform ALDH3A1 | Oryctolagus cuniculus | 5737 | - |
nucleus | - |
Mus musculus | 5634 | - |
nucleus | isoform ALDH3A1 | Oryctolagus cuniculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxy-2-nonenal + NAD+ + H2O | Oryctolagus cuniculus | - |
4-hydroxynon-2-enoate + NADH + H+ | - |
? | |
4-hydroxy-2-nonenal + NAD+ + H2O | Mus musculus | - |
4-hydroxynon-2-enoic acid + NADH | - |
? | |
4-hydroxy-2-nonenal + NAD+ + H2O | Mus musculus | poor substrate of isoform ALDH3A1 | 4-hydroxynon-2-enoic acid + NADH | - |
? | |
malondialdehyde + NAD+ + H2O | Mus musculus | - |
? | - |
? | |
malondialdehyde + NAD+ + H2O | Oryctolagus cuniculus | poor substrate of isoform ALDH3A1 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P47738 | isoform ALDH2 | - |
Mus musculus | Q3UNF5 | isoform ALDH3A1 | - |
Mus musculus | Q9CZS1 | isoform ALDH1B1 | - |
Mus musculus | Q9DBF1 | isoform ALDH7A1 | - |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cornea | - |
Mus musculus | - |
keratocyte | - |
Oryctolagus cuniculus | - |
lens | - |
Mus musculus | - |
TRK-43 cell | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxy-2-nonenal + NAD+ + H2O | - |
Oryctolagus cuniculus | 4-hydroxynon-2-enoate + NADH + H+ | - |
? | |
4-hydroxy-2-nonenal + NAD+ + H2O | - |
Mus musculus | 4-hydroxynon-2-enoic acid + NADH | - |
? | |
4-hydroxy-2-nonenal + NAD+ + H2O | poor substrate of isoform ALDH3A1 | Mus musculus | 4-hydroxynon-2-enoic acid + NADH | - |
? | |
malondialdehyde + NAD+ + H2O | - |
Mus musculus | ? | - |
? | |
malondialdehyde + NAD+ + H2O | poor substrate of isoform ALDH3A1 | Oryctolagus cuniculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | isoform ALDH3A1 | Oryctolagus cuniculus |
homodimer | isoform ALDH3A1 | Mus musculus |
homotetramer | isoform ALDH1B1 | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
Aldh1b1 | isoform, formerly known as ALDHx or ALDH5 | Mus musculus |
ALDH2 | isoform | Mus musculus |
ALDH3A1 | isoform | Oryctolagus cuniculus |
ALDH3A1 | isoform | Mus musculus |
Aldh7a1 | isoform | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Oryctolagus cuniculus | |
NAD+ | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Oryctolagus cuniculus | isoform ALDH3A1 protein and mRNA levels increase substantially in mouse cornea by postnatal day 14 | up |
Mus musculus | isoform ALDH3A1 protein and mRNA levels increase substantially in mouse cornea by postnatal day 14 | up |
General Information | Comment | Organism |
---|---|---|
malfunction | decreased ALDH3A1 activity is associated with pathologic corneas (cataract development) | Oryctolagus cuniculus |
malfunction | decreased ALDH3A1 activity is associated with pathologic corneas (cataract development) | Mus musculus |
metabolism | isoform ALDH3A1 may exhibit antioxidant activity indirectly by producing NADH during metabolism | Oryctolagus cuniculus |
metabolism | isoform ALDH3A1 may exhibit antioxidant activity indirectly by producing NADH during metabolism | Mus musculus |
physiological function | isoform ALDH1A1 plays a protective role against ultraviolet radiation-induced oxidative damage to ocular tissues | Mus musculus |
physiological function | isoform ALDH3A1 plays a protective role against ultraviolet radiation-induced oxidative damage to ocular tissues. The nuclear presence of isoform ALDH3A1 may be involved in cell cycle regulation | Mus musculus |
physiological function | isoforms ALDH3A1 plays a protective role against ultraviolet radiation-induced oxidative damage to ocular tissues. The nuclear presence of isoform ALDH3A1 may be involved in cell cycle regulation | Oryctolagus cuniculus |