Application | Comment | Organism |
---|---|---|
medicine | the results suggest that GAPDH is an active regulator in the phosphoinositide-mediated signaling pathway and a potential new target for insulin resistance treatment, diabetes, obesity and aging research | Oryctolagus cuniculus |
medicine | the results suggest that GAPDH is an active regulator in the phosphoinositide-mediated signaling pathway and a potential new target for insulin resistance treatment, diabetes, obesity and aging research | Caenorhabditis elegans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-Hydroxydopamine | - |
Oryctolagus cuniculus | |
GAPDH segregator | GAPDS stimulates insulin signaling by segregating the tetrameric GAPDH into monomers, and thereby suppresses the intrinsic GAPDH activation of phosphoinositide's phosphatase activity | Caenorhabditis elegans | |
GAPDH segregator | GAPDH segregator, GAPDS, stimulates insulin signaling by segregating the tetrameric GAPDH into monomers, and thereby suppresses the intrinsic GAPDH activation of phosphoinositide's phosphatase activity | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | - |
Oryctolagus cuniculus | - |
Subunits | Comment | Organism |
---|---|---|
homotetramer | - |
Oryctolagus cuniculus |
tetramer | - |
Caenorhabditis elegans |
Synonyms | Comment | Organism |
---|---|---|
GAPDH | - |
Oryctolagus cuniculus |
GAPDH | - |
Caenorhabditis elegans |
glyceraldehyde-3-phosphate dehydrogenase | - |
Oryctolagus cuniculus |
glyceraldehyde-3-phosphate dehydrogenase | - |
Caenorhabditis elegans |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.008 | - |
- |
Oryctolagus cuniculus | 6-Hydroxydopamine | |
0.015 | - |
GAPDS inhibits the glycolytic enzymatic function of GAPDH | Oryctolagus cuniculus | GAPDH segregator |