Cloned (Comment) | Organism |
---|---|
high-level overexpression of RNR subunits, Rrm1, Rrm2 and p53R2, separately or in different combinations, in mice, simultaneous expression of two RNR subunits | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of RNR transgenic mice expressing one or more subunits of RNR, phenotypes, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
ribonucleotide reductase | - |
Mus musculus |
RNR | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | endogenous RNR transcripts are downregulated in response to large increases of mtDNA in mice, which is indicative of nuclear-mitochondrial crosstalk with regard to mtDNA copy number | down |
General Information | Comment | Organism |
---|---|---|
metabolism | RNR is the rate-limiting enzyme in deoxyribonucleoside triphosphate, dNTP, biosynthesis | Mus musculus |
additional information | high-level overexpression of RNR subunits, Rrm1, Rrm2 and p53R2, separately or in different combinations, in mice does not result in mtDNA copy number elevation. Instead, simultaneous expression of two RNR subunits leads to imbalanced dNTP pools and progressive mtDNA depletion in the skeletal muscle, without mtDNA mutagenesis, overview | Mus musculus |
physiological function | RNR is the rate-limiting enzyme in deoxyribonucleoside triphosphate, dNTP, biosynthesis, with important roles in nuclear genome maintenance. RNR is also essential for maintenance of mitochondrial DNA in mammals | Mus musculus |