Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Hydroxyurea | inactivates both Ia/b and Ic beta2 subunits by reducing their C oxidants, reacts with the MnIV/FeIII cofactor to give two distinct products: the homogeneous MnIII/FeIII-beta2 complex, which forms only under turnover conditions, in the presence of alpha2 and the substrate, and a distinct, diamagnetic Mn/Fe cluster, which forms about 900fold less rapidly as a second phase in the reaction under turnover conditions and as the sole outcome in the reaction of MnIV/FeIII-beta2 only | Chlamydia trachomatis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe3+ | MnIV/FeIII cofactor | Chlamydia trachomatis | |
Mn(IV) | MnIV/FeIII cofactor | Chlamydia trachomatis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Chlamydia trachomatis | catalysis by a class I RNR begins when a cysteine residue in the alpha2 subunit is oxidized to a thiyl radical by a cofactor about 35 A away in the beta2 subunit. In a class Ia or Ib RNR, a stable tyrosyl radical is the C oxidant, whereas a MnIV/FeIII cluster serves this function in the class Ic enzyme from Chlamydia trachomatis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chlamydia trachomatis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | catalysis by a class I RNR begins when a cysteine residue in the alpha2 subunit is oxidized to a thiyl radical by a cofactor about 35 A away in the beta2 subunit. In a class Ia or Ib RNR, a stable tyrosyl radical is the C oxidant, whereas a MnIV/FeIII cluster serves this function in the class Ic enzyme from Chlamydia trachomatis | Chlamydia trachomatis | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | alpha2beta2, with subunits alpha1, alpha2, beta1, and beta2 | Chlamydia trachomatis |
Synonyms | Comment | Organism |
---|---|---|
class I RNR | - |
Chlamydia trachomatis |
class Ic ribonucleotide reductase | - |
Chlamydia trachomatis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
MnIV/FeIII cofactor | electron transfer mechanism and conformational identification, role in reaction and mechanism, detailed overview | Chlamydia trachomatis |