Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Molybdenum | in the molybdopterin cofactor | Bagrus bajad |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxanthine + NAD+ + H2O | Bagrus bajad | - |
xanthine + NADH + H+ | - |
? | |
xanthine + H2O + O2 | Bagrus bajad | - |
urate + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bagrus bajad | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
spleen | - |
Bagrus bajad | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxanthine + NAD+ + H2O | - |
Bagrus bajad | xanthine + NADH + H+ | - |
? | |
xanthine + H2O + O2 | - |
Bagrus bajad | urate + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
XOR | - |
Bagrus bajad |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
molybdopterin | - |
Bagrus bajad | |
NAD+ | - |
Bagrus bajad |
Organism | Comment | Expression |
---|---|---|
Bagrus bajad | the enzyme is upregulated and enzyme activity increases in the spleen of animals infected with Aeromonas caviae, as do the splenic levels of uric acid, reactive oxygen species, and metabolites of nitric oxide (NOx), compared to the uninfected control group | up |
General Information | Comment | Organism |
---|---|---|
malfunction | upregulation of splenic xanthine oxidase activity contributes to disease pathogenesis of Aeromonas caviae infection, as well as whether it may be considered a pathway involved in reactive oxygen species (ROS) and nitric oxide (NO) production. Excessive uric acid induces the release of pro-inflammatory mediators, such as ROS and NOx, which contribute to disease pathophysiology, in spleen tissue they contribute to oxidation and inflammation of the tissue | Bagrus bajad |
physiological function | xanthine oxidoreductase (XOR) is a molybdopterin-containing enzyme that catalyzes the oxidation of hypoxanthine to xanthine, and further generates uric acid from xanthine in the purine metabolic pathway | Bagrus bajad |