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Literature summary for 1.17.3.2 extracted from
- In vitro activation of dibromoacetonitrile to cyanide: role of xanthine oxidase (2003), Arch. Toxicol., 77, 86-93.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | enhance oxidation of dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system | Bos taurus |  |
| glutathione | enhances oxidation of dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system | Bos taurus | |
| N-acetyl-L-Cys | enhance oxidation of dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system | Bos taurus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| allopurinol | competitive inhibition of oxidation of dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system | Bos taurus | |
| desferrioxamine | significant decrease in CN- formation from dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system | Bos taurus | |
| dimethylthiourea | significant decrease in rate of oxidation of dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system | Bos taurus | |
| folic acid | uncompetitive inhibition of oxidation of dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system | Bos taurus | |
| mannitol | significant decrease in rate of oxidation of dibromoacetonitrile by the hypoxanthine/xanthine oxidase/Fe system | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 97 | - |
dibromoacetonitrile | - |
Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dibromoacetonitrile + H2O + O2 | - |
Bos taurus | ? | - |
r | |
| additional information | hydroxyl free radicals generated by the hypoxanthine/xanthine oxidase/Fe system are implicated in oxidation of dibromoacetonitrile to CN- | Bos taurus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
conversion of dibromoacetonitrile to CN- | Bos taurus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | 45 | 30°C: about 60% of maximal activity, 45°C: about 75% of maximal activity, conversion of dibromoacetonitrile to CN- | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
conversion of dibromoacetonitrile to CN- | Bos taurus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 9.5 | pH 6.5: about 40% of maximal activity, pH 9.5: about 65% of maximal activity, conversion of dibromoacetonitrile to CN- | Bos taurus |
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