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Literature summary for 1.16.1.2 extracted from
- Diferric transferrin reductase in Plasmodium falciparum-infected erythrocytes (1989), Biochem. Biophys. Res. Commun., 158, 469-473.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| apotransferrin | - |
Plasmodium falciparum | |
| additional information | sensitive to treatment with trypsin | Plasmodium falciparum |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasmic membrane | erythrocytes infected with Plasmodium falciparum, synthesis and incorporation of the enzyme by the intraerythrocytic parasite | Plasmodium falciparum | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| transferrin[Fe(III)]2 + NADH | Plasmodium falciparum | enzyme of the malaria parasite Plasmodium falciparum together with parasite-derived transferrin receptor in the erythrocyte membrane forms a transferrin receptor-mediated uptake mechanism of iron | transferrin[Fe(II)]2 + NAD+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium falciparum | - |
malaria parasite, erythrocytes infected with Plasmodium falciparum | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | infected with Plasmodium falciparum, synthesis of the enzyme by the intraerythrocytic parasite | Plasmodium falciparum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ferritin[Fe(III)] + NADH | - |
Plasmodium falciparum | ferritin[Fe(II)] + NAD+ | - |
? | |
| transferrin[Fe(III)]2 + NADH | - |
Plasmodium falciparum | transferrin[Fe(II)]2 + NAD+ | - |
? | |
| transferrin[Fe(III)]2 + NADH | enzyme of the malaria parasite Plasmodium falciparum together with parasite-derived transferrin receptor in the erythrocyte membrane forms a transferrin receptor-mediated uptake mechanism of iron | Plasmodium falciparum | transferrin[Fe(II)]2 + NAD+ | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Plasmodium falciparum | |
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